ID A0A091GZU3_BUCRH Unreviewed; 605 AA.
AC A0A091GZU3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Calpain-8 {ECO:0000313|EMBL:KFO88719.1};
DE Flags: Fragment;
GN ORFNames=N320_11464 {ECO:0000313|EMBL:KFO88719.1};
OS Buceros rhinoceros silvestris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO88719.1, ECO:0000313|Proteomes:UP000054064};
RN [1] {ECO:0000313|EMBL:KFO88719.1, ECO:0000313|Proteomes:UP000054064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO88719.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; KL518241; KFO88719.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091GZU3; -.
DR Proteomes; UP000054064; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd16191; EFh_PEF_CAPN8; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF374; CALPAIN-8; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..605
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001874201"
FT DOMAIN 1..243
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 499..534
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 4
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 161
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 185
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO88719.1"
FT NON_TER 605
FT /evidence="ECO:0000313|EMBL:KFO88719.1"
SQ SEQUENCE 605 AA; 68852 MW; 876BA7173878C8C9 CRC64;
LGDCWLLAAI ASLTLNPDVL YRVVPNDQSF QKDYAGIFHF QFWQYGEWVD VVVDDRLPTK
NGKLVFVHSE EGNEFWSALL EKAYAKLNGS YEALAGGSTM EGFEDFTGGI SESYLLRKAP
PNLYQIIQKA LRAGSLLGCS IDITSAAEIE AITSLKLVKG HAYSVTGAEE VYYRGRTEKL
VRLRNPWGEV EWTGAWSDNA PEWNYVDPKQ KQALDKQVDD GEFWMAYSDF QRQFTRLEIC
NLTPDTLASN EVNKWNLTLF NGQWRRGSTA GGCQNYQATY WTNPQFKIRL DEPDDDHEGS
LDEPCCTILV GLMQKNRRRQ KRMGEALLSI GYSLYQLENN TDIHANRVFF ATHQPAARSD
PYVNLREVSS RMKLPRGEYL IVPSTFEPYK NGEFCLRVFS EKHAKTQMIG DVVSAKPYEP
HVDSKGIDDE FKTLFQKLSG EDWEVTAIEL QTILNRVLAK RKDVKSDGFD INTCREMISL
FDTNGTGTLG LVEFKTLWMK IQKYLAIYKK VDSDYSGTID SHEMRNALRE AGGENCPGES
FMLNDQVQHS IVTRYACSKL TIDFDGFVAC MVRLETLFKV FRLLDKDKSG VIQLSLAEWL
CCTLV
//
