ID A0A091H102_BUCRH Unreviewed; 425 AA.
AC A0A091H102;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Dorsalin-1 {ECO:0000313|EMBL:KFO89109.1};
DE Flags: Fragment;
GN ORFNames=N320_04200 {ECO:0000313|EMBL:KFO89109.1};
OS Buceros rhinoceros silvestris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO89109.1, ECO:0000313|Proteomes:UP000054064};
RN [1] {ECO:0000313|EMBL:KFO89109.1, ECO:0000313|Proteomes:UP000054064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO89109.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KL519384; KFO89109.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091H102; -.
DR Proteomes; UP000054064; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19400; TGF_beta_BMP9; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF157; GROWTH_DIFFERENTIATION FACTOR 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..425
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001875729"
FT DOMAIN 313..425
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 285..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO89109.1"
FT NON_TER 425
FT /evidence="ECO:0000313|EMBL:KFO89109.1"
SQ SEQUENCE 425 AA; 48063 MW; F243FA6BBFF11EE7 CRC64;
FGVLAVLSVF NIIACLTRGK PLEDWDKLPA MGKSETYFHD TGEVKDENHF NVKSFLENMK
TDLLRSLNLS RVPSQVKTKE EPPQFMIDLY NRYTADKSSI PASNIVRSFS TEDVVSSASA
EENPFQKHIL LFNISIPRYE EITRAELRIY ISCHREVGSL SRLEGNMVIY DVLDGDHWEN
PESTKSFLVS HNIQECGWEM FEVSSAVKRW VRADKLKTKN KLEVVIESKA LGSFTCGKLD
ISVTPDTKNL PLLIVFSNDR SNGTKETKVE LREMIVHEQE SVLKKLGKNN TSSEEEEQGE
EKAITGPHQH SSRSKRSTGV NHCRRTSLHV NFKEIGWDSW IIAPKDYEAF ECKGGCFFPL
TDNVTPTKHA IVQTLVHLQN PKKASKACCV PTKLDAISIL YKDHAGVPTL IYNYEGMKVA
ECGCR
//
