ID   A0A091H354_9AVES        Unreviewed;      3808 AA.
AC   A0A091H354;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
DE   Flags: Fragment;
GN   ORFNames=N303_14882 {ECO:0000313|EMBL:KFO80727.1};
OS   Cuculus canorus (common cuckoo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX   NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO80727.1, ECO:0000313|Proteomes:UP000053760};
RN   [1] {ECO:0000313|EMBL:KFO80727.1, ECO:0000313|Proteomes:UP000053760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO80727.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL448130; KFO80727.1; -; Genomic_DNA.
DR   STRING; 55661.A0A091H354; -.
DR   Proteomes; UP000053760; Unassembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR049400; DYNC2H1_AAA_dom.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053760}.
FT   DOMAIN          1664..1810
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          1951..2107
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2263..2411
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          1057..1084
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2913..2957
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3083..3173
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO80727.1"
FT   NON_TER         3808
FT                   /evidence="ECO:0000313|EMBL:KFO80727.1"
SQ   SEQUENCE   3808 AA;  435736 MW;  E4F9EFDFC08198C8 CRC64;
     NFFGLEPALA VGLRSCPRLS AFLDDGNEFL LVVRRSGGSL SASNQIEATD SKNNVLVFFK
     LRPDVITEDN LHSNILVSSM LDSPINTLYQ AVRQVFAPVL LKDERWSKTF DPKLQKLLSE
     LEAGLSTVLR RSDPNYTGTK FSEDDVRAIL TPTDEFQFWV ECARHGSKWC SKERASHFKD
     LFEDIAKDYY NLDSLSLFEV VDLVETTKDT VDGVWRQTEH DPYPQPRMHN LLDVIGGSLG
     RYVQRKLAAL NLWEDAFYSI KENLKAGILI CEQWVSACDY LTGQLWQRYT LHPWQNEKYF
     PESLAKLGKR LDEVLTVRTL HEKLTFFLPA GEQNALHLAQ AFEPFAGLNP VHYNPYTEPL
     WKAAVSQYER IIAPAEQKIA SKLKKFIAEI QDSPQQLLQT FQKYKELIKH PNISKELLFE
     RETLLARLQD YVKDYQTDFE TRCHGVPGDV SGPLSGKNLS EVVNNIVWVQ QLELKVDDAT
     KLAEALLSDL PGCQAFHRSA DSFLEQLKAY EQEQFDDWSR NIQSELSNPK SGLCIQANSP
     IMELDHVSGT LNILYSDRLV TLLREVRQLA ALGFAIPANI QRVANTAQKF CKQAVILKQV
     AHFYNSIDQQ MIESQKPMML QSALAFEQII KHSKSGPGGR AQITWDNPRE LEVYIQKLQA
     AAERLSTENR KLRKWHTNFI EKVILLMNVD LLRQQQRWKD GLQELRTAFT SLQSQAGFHY
     RIANSWRQHW NHQLYKALEH QYQMGLEALN ENLPEINIDL TFKQGRLQFR PPFEEVRARY
     YREMKRFISI PNQFRGVSEA EEESIFTVMT ERNANGFLTA FGKAEDLFRR LTDVSNQFKE
     WIVIGQVDME TLVKTHLSSK QDWEKNFKAL KVRGKEAERL PSTIRIDCLT VNCNPVKTVI
     DDFIQKLYDV LVISLRKSIQ AHLCDVSSFL TDAMETLVIR PQTVEEIAED NAKYLNLREQ
     KEGVFLLFQE AEDKNKLLRT VAGAGLDTLS NLRAAWDKFE LMMESHQLMI TEQIEMMKGN
     VISHINVYLQ DLEKFKARWD QLKPGDDVIE TGDQDVLEKS AQIIKEKKKE FDELETVKEK
     LIEECHHFKL DEPDFSLSEV VCQDIKNCAE VWALYEEFYQ GFQEKAKEDW ITFRSKTYLF
     EEFLFNWHDK MRKMGEHTVM TAKLQKEVDK YKMVIPLLKY VRGEHLSPDH WLDLFRILGL
     PRGTTLEGLL FGDLLKVTDT IIDKAMELKD LNCRAQGEVT IREALRELEL WGVGAVFTLT
     DYEDSQGRTI RLIKDWKDIV NQVGDHRCLL QSLKDSPYYK GFEDKVSIWE KKLAELDEYL
     QNLNQIQRKW VYLEPIFGRG SLPKEQARFN RVDEDFRSIM SDIKNDNRIT SLNARTGIRN
     TLITLLDQLQ RCQRSLNEFL EEKRSAFPRF YFIGDDDLLE ILGQSTNPLV IQSHLKKLFA
     GINSVSFDEE FKYIIAMKSV EGETVPLRNK VLLSNDVEVW LNSLALEMKE TLKVMLIDCV
     DAGKKSQGSI DPSLFPSQIL SLAEQIQFTE DVESAIKDHN LQQLELELMA KLEHYTSIDT
     SIEDTGSTES GILELKLKAL ILDIVHNIDV VKQLNQARVH SVQDWAWKKQ LRFYMKDQKC
     YVQMVDAELQ YTYEYQGNSP KLVYTPLTDK CYLTLTQAMK MGLGGNPYGP AGTGKTESVK
     ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF DEFNRLEEAV LSAVSMQIQT
     IQHALKKHSP VCEMLGKKVE MDHNSGIFIT LNPAGKGYGG RQKLPDNLKQ LFRPVAMTHP
     DNELIAEVIL YSEGFKDAKI LGRKLVAIFN LAREFLTPQQ HYDWGLRALK TVLRGCGSLL
     HQMKKSEAKQ EIKESHMVVQ ALRLNTMSKL TFADCARFDA LVKDVFPGID FKDVEYAELT
     TALQQVFEEA NLEIISAQIK KALELYEQLR QRMGVVIVGP SGAGKSTLWR MLKAALGKTG
     KVVKQYTMNP KAMPRHQFLG HIDMDTREWS DGVLTNSARQ VVREPRDITS WIICDGDIDP
     EWIESLNSVL DDNRLLTMPS GERIQFGSNV NFIFETHDLS CASPATISRM GMIFLSDEDT
     DLNSLIKSWL RSQPEECRYN LENWIGDYFE KALNWVVKKN DSVVETSLVG TVMNGLSHLH
     GCTDRGQFII NLLRGLGGNL NMKSRQEFAE EIFSWARESP PDPRKPLDTY YDTDTGHLML
     YHLKKPEKLT ADDFSNPQTL PVIQTPDMQR GLDYFRPWLD FNYKQPFLLV GPEGCGKGML
     LHYAFSQLRS TQIATIHCSA QTTSQHLLQK LSQTCIVIST NTGRVYRPKD CERLVLYLKD
     INLPKPDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI QIVASMSAGG TLGRHKLTSR
     FTSIVRLCAI DYPERDQLQA IYSAYLEPVL QKNLTNHRVW GSLPNIHQLA GSMVQVYEQV
     RAKFTVDDHS HYLFTPCILT QWVLGLFRYD LAGGSLTQTA DYVLEIVAYE ACRLFRDKIV
     GMKELHVFDN VLMKVFQDDW GSDVLDNTAD VFYVTWGACQ EAFVTPGQGL PPHGRPLGRL
     NSTDLKDIIQ KGIIHYGRDK KEIEILLFHE VLSYMSKVDR VLSFPGGSLL LAGRSGVGRR
     TVTSLVSHMH GAVLITPKIS RGYELKQFRN DLKYVMELAG IEAQQVVLLL EDYQIVHSTF
     LEMINSLLSS GEVPGLYKVE ELEPLLSPLK DQASQDGFTG PIFNYFTYRI QQNLHVVLIM
     DSTNINFTIN CESNPALYKK CQVLWMETWS ENSMRKIPEM LLCDSDEQEK TGKTNKAHKQ
     KHSGDSDFLK SFLTIHESCK MYGATPSRYM TFLRIYSTIN NSKRQELIKR QNHLQAGVSK
     LNEAKVLVDE LNRKAGEQSI LLKTKQDEAD AALQEITVSM QNASEQKTEM EKLKHRIAEE
     AAEIEERKRK IEDELKEVQP LVNEAKLAVG NIKPESLSEI RSLRMPPDII RDILEGVLRL
     MGIFDTSWVS MKSFLAKRGV REDIATFDAR NIPKEIRESV EELLSRNRTS FDPKNAKRAS
     AAAAPLAAWV NANVQYSHVL ERIQPLEKEK AGLEANLKKT EGRKRKLEDL LNSVGQKVSE
     LKEKFQSRTT EAAKLEAELS KAQKTLKAAE VLINQLDREH KRWSTQVSEI TEELATLPKR
     AQLAAAFITY LSAAPEDQRK NSLEEWTKSA GLEKFDLRRF LCTESEELVW KSEGLPSDDL
     SIENALVILQ SKVCPFLIDP SFRATEWLKT HLKESRLEVI NQQDNNFLTA LELAVRFGKT
     LIIQEMDGVE PVLYPLLRKD LIAQGPRYAV QIGEKTIDYN EEFRLFLSTR NPNPFIPPDA
     SSIVTEVNFT TTGSGLRGQL LALTIQHEKP DLEEQKTKLL QQEEEKKIQL AKLEESLLET
     LATSQGNILE NKDLIESLNQ TKASSAVIQE SLAESHRLQS FLDKERDAYL PLAESASKMY
     FIISDLSKIN NMYRFSLAAF LRLFQRALLS EQVSSNTEDR IKSLIGSLKH TVYEYVCRCL
     FKADQLMFTL HFVRGMHPEL FQENEWETFT GVIIGDTIRK SDSQRSIRDQ IPSWIEQDRA
     WAVASLKISL PGLYQTLCFE DESLWRTFSR SSVCEQDFPS TIVKRISLFQ QVLVVQAVRP
     DRLQSAMALF ACKTLGIKEL SPSPLSLKRL YKETLEIEPI LIIISPGADP SQELQELAGI
     ERNTECYHQI AMGQGQADLA IQTLKECARN GEWLCLKNLH LVTSWLPVLE KELNMLQPQP
     NFRLWLTTEV HPKFTPILLQ SSLKITYE
//