ID A0A091H6E7_9AVES Unreviewed; 1010 AA.
AC A0A091H6E7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-1 {ECO:0000313|EMBL:KFO81827.1};
DE Flags: Fragment;
GN ORFNames=N303_03576 {ECO:0000313|EMBL:KFO81827.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO81827.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO81827.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO81827.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
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DR EMBL; KL448279; KFO81827.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091H6E7; -.
DR STRING; 55661.A0A091H6E7; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 158..335
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO81827.1"
FT NON_TER 1010
FT /evidence="ECO:0000313|EMBL:KFO81827.1"
SQ SEQUENCE 1010 AA; 114692 MW; A37ADF35DFB1D103 CRC64;
LQRLAKEAEK YQASHQWRDE FGNNDIIYYN AKDDQNDPEK NDTESGSQRI RPVFEEDPVF
RRQTSYQHAA VHIPTDIYEG STIVLNELNW TAALDDVFKR NREEDPTLLW QVFGSATGLA
RYYPASPWVD NSRTPNKIDL YDVRRRPWYI QGAASPKDML ILVDASGSVS GLTLKLIRTS
VIEMLETLSD DDFVNVVSFN NNAQNVSCFN HLVQANVRNK KKLKEAVYKI SAKGITDYKK
GFSYAFEQLL NHSVSRANCN KIIMLFTDGG EERAQEIFHK YNEDKKVRVF TFSVGQHNYD
KGPIQWMACE NKGYYYEIPS IGAIRINTQE YLDVLGRPMV LAGEKAKQVQ WTNVYLDALE
LGLVITGTLP VFNLTKEQNG KINQLILGVM GVDVSLEDIK KLTPRFTLCP NGYYFAIDPN
GYVLLHPNLQ PKQIGVGIPK VKLRKRRPNV QNPKSQEPVT LDFLDAELEN DIKVEIRKKM
IDGESGEKTF ETLVKSQDER YIDKGNRTYT WTAVNGTDYS LALVLPSYSF YYIKAKIEEP
ITQARCKYYE VTETLKIDHF DEAGYTFIAP REYCSDVKKS ENNTEFLLNF NEFIDRYTPS
SASCNTDMVL RVLLDAGFTN ELAQNYWSKL SLDGVVAHFV VTDGGITRVF PKRAGEVWLE
NAETYEVSFY KRSLDNDNYI FTAPYYNKSG ANSYETGIMV SKAVEITVDG KLLKPAVVGI
KIDATSWMEN FTKTTIKSLC NSEICGCERN SMHVDCVILD DGGFLLMSNR DEYTQQIGRF
FGEIDPGLMR NLINMSLYAF NKSYDYQSVC DPEEEPKQGA GLRSAYVPTI TDILHLGWWA
SAAAWSILQQ LFLSLTFPRF LEAADMEDDD FGAALPKTSC ITEQTQYFFE NDDKSFGGIV
DCINCSRLYH AEKISNTNLV FIISDSQLLC RSCDPKPLMQ AEKPDEGPNP CEMVKQPRYR
KGPDVCFDEA KQEDSADCGG VSGLSPSLWS MVGIQLVLLW LLSGSRHCQL
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