ID   A0A091H822_BUCRH        Unreviewed;       549 AA.
AC   A0A091H822;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Polycystin-2 {ECO:0000313|EMBL:KFO90855.1};
DE   Flags: Fragment;
GN   ORFNames=N320_12348 {ECO:0000313|EMBL:KFO90855.1};
OS   Buceros rhinoceros silvestris.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX   NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO90855.1, ECO:0000313|Proteomes:UP000054064};
RN   [1] {ECO:0000313|EMBL:KFO90855.1, ECO:0000313|Proteomes:UP000054064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO90855.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004272}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004272}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the polycystin family.
CC       {ECO:0000256|ARBA:ARBA00007200}.
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DR   EMBL; KL524980; KFO90855.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091H822; -.
DR   Proteomes; UP000054064; Unassembled WGS sequence.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   InterPro; IPR003915; PKD_2.
DR   InterPro; IPR046791; Polycystin_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10877:SF114; POLYCYSTIN-2; 1.
DR   Pfam; PF08016; PKD_channel; 1.
DR   Pfam; PF20519; Polycystin_dom; 1.
DR   PRINTS; PR01433; POLYCYSTIN2.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022882};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        26..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        400..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        462..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          71..265
FT                   /note="Polycystin"
FT                   /evidence="ECO:0000259|Pfam:PF20519"
FT   DOMAIN          267..490
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   DISULFID        133..146
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO90855.1"
FT   NON_TER         549
FT                   /evidence="ECO:0000313|EMBL:KFO90855.1"
SQ   SEQUENCE   549 AA;  64018 MW;  67F0107B2F6B9BB4 CRC64;
     GLWGTRLMEE SNTSRERYLK SVLRELVTYI IFLVVLCVLT YGTVSSNMYY YTRVMSQLFL
     ETPVSKMDKT DFKTLSTMDD FWKFTEGPLL DGLYWEMWYN NKTMAENKSL IYYENLLLGV
     PRIRQLKVRN GSCSIPEDLK DEIKDCYDVY SVANEDTAPF GLRNGTAWTY TNEKDLNGSS
     HWGLIATYSG AGYYQDLSRT REVTAVQIAR LKKNLWLDRG TRAAFIDFSV YNANINLFCI
     VRLLVEFPAT GGLVTSWQFQ PVRLIHYIST FDFFLAACEM AFCLFVLYYM VEEILEIHIH
     RLHYFRSLWN CLDILILVLS TVAIGISIYR TSTVDVLLKK LLEDQNLFPN FEPLAYWQMQ
     FNNIAAVTVF FVWIKLFKFI NFNRTMCQLS TTMSRCVKDV IGFAIMFFII FLAYAQLAYL
     VFGTQIDDFS TFQDCIFTQF RIILGDFNFT EVEEANRILG PIYFTTFVFF MFFILLNMFL
     AIINDTYSEV KSDMAQQKAE MELSDLIRKG YNKAMIKLKL KKSTVDDISE SLRQGGGKLN
     FDELRQDLK
//