ID A0A091HM45_CALAN Unreviewed; 577 AA.
AC A0A091HM45;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Complement component C8 beta chain {ECO:0000256|ARBA:ARBA00013949};
DE AltName: Full=Complement component 8 subunit beta {ECO:0000256|ARBA:ARBA00031383};
DE Flags: Fragment;
GN ORFNames=N300_00613 {ECO:0000313|EMBL:KFO96279.1};
OS Calypte anna (Anna's hummingbird) (Archilochus anna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC Trochilidae; Calypte.
OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFO96279.1, ECO:0000313|Proteomes:UP000054308};
RN [1] {ECO:0000313|EMBL:KFO96279.1, ECO:0000313|Proteomes:UP000054308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFO96279.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Constituent of the membrane attack complex (MAC) that plays a
CC key role in the innate and adaptive immune response by forming pores in
CC the plasma membrane of target cells. {ECO:0000256|ARBA:ARBA00002409}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KL217539; KFO96279.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091HM45; -.
DR STRING; 9244.A0A091HM45; -.
DR Proteomes; UP000054308; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF5; COMPLEMENT COMPONENT C8 BETA CHAIN; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..577
FT /note="Complement component C8 beta chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001874450"
FT DOMAIN 144..490
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT REGION 555..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 126..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO96279.1"
FT NON_TER 577
FT /evidence="ECO:0000313|EMBL:KFO96279.1"
SQ SEQUENCE 577 AA; 64726 MW; 60755705FF22D53B CRC64;
KLVLLHALLS ILNVHCFGGE KLSLNFSSTN KSTANTRSTR SVSNLPQPRD CLLSPWSSWS
KCDPCQKKRY RFARLEQPSQ FNGDPCDYSD RETEDCVTNN PCRNKVPCDG FVCAVTGRCI
TRRLLCNGDD DCGDQSDEKN CKKVFKKCDQ KMEQYWGIEN LAKGLNIFTN NLEGLVLDHR
YYAGGCSPHY IVDTRFRKPY NVESYVPETT GKYEFTMTEY NSYSNYESFV LKAKAEQSGF
SFGIKIPGLF ELGYSSNDNR FQKFIQRMKR FSSTSSSFIH ARSELAVGVY KLKPQSLMLH
YEFQQRLQQL PVEYSYGEYR ELYRDYGTHY ITEATVGGIY EYTLVINSQE LQKAGYSLSD
VQKCAQHGFN IGANIYQVYG KLGITAAGCK SLLKEIGDST SSKRFVEDFI VLVRGGASEH
ITALAYRDLP TAALLQEWGD AVQYNPEIIK LKAEPLFQLV TPRDLAQAAA IKENLRRALE
EFQLESSSCH CAPCHGNGIP FLRGSKCECL CPLGYSGPAC ETSKRTDAAV NGNWGCWSSW
SSCAGGERRR RRLCKNPGPE TDAGSACSGP DTETLAC
//
