ID   A0A091HPH3_CALAN        Unreviewed;       683 AA.
AC   A0A091HPH3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Epidermal growth factor receptor kinase substrate 8-like 2 {ECO:0000313|EMBL:KFO97771.1};
DE   Flags: Fragment;
GN   ORFNames=N300_10679 {ECO:0000313|EMBL:KFO97771.1};
OS   Calypte anna (Anna's hummingbird) (Archilochus anna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC   Trochilidae; Calypte.
OX   NCBI_TaxID=9244 {ECO:0000313|EMBL:KFO97771.1, ECO:0000313|Proteomes:UP000054308};
RN   [1] {ECO:0000313|EMBL:KFO97771.1, ECO:0000313|Proteomes:UP000054308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N300 {ECO:0000313|EMBL:KFO97771.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the EPS8 family.
CC       {ECO:0000256|ARBA:ARBA00006197}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL217671; KFO97771.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091HPH3; -.
DR   STRING; 9244.A0A091HPH3; -.
DR   Proteomes; UP000054308; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01210; PTB_EPS8; 1.
DR   CDD; cd09540; SAM_EPS8-like; 1.
DR   CDD; cd11764; SH3_Eps8; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR039801; EPS8-like.
DR   InterPro; IPR033928; EPS8_PTB.
DR   InterPro; IPR035462; Eps8_SH3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013625; PTB.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041418; SAM_3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12287:SF20; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR   Pfam; PF08416; PTB; 1.
DR   Pfam; PF18016; SAM_3; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:KFO97771.1};
KW   Receptor {ECO:0000313|EMBL:KFO97771.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:KFO97771.1}.
FT   DOMAIN          457..516
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          155..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..208
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO97771.1"
FT   NON_TER         683
FT                   /evidence="ECO:0000313|EMBL:KFO97771.1"
SQ   SEQUENCE   683 AA;  78639 MW;  DD6019576509976B CRC64;
     EQRKKYSNSN IIMHETSQYH VQHLATFIMD KSESIVTVDD AIRKLILLNS KEKIWTQEML
     LQVNDKSIRL LDCESQEELE DFPLPTVQHC QTVLNQLRYS SILLLVCQDS EQHKPDIHFF
     NCDEVEAEMV HEDIESALAD HKHGKKIRPQ TLKANQEKIK QRQSILPPPQ GPAPIPIQHD
     RNSRNRVAPP SHHNPDYDRR SSHEHEESRA ILAQKIEKET QILNCTLDDI EVFVARLQKA
     AEAFKQLNQR KKGKKNKKKG PAEGMLTLRA RPPSEAEFID CFQKTKLAFN LLAKLRKHIQ
     NPSASELVHF LFGPLELIIS SCGGPELARS VVSPLLSKDA TDFLRGHLTP KEINLWDSLG
     ETWTRSRAEW PREANIPTYI PKFRNGWEPP IEIFRGAPWE IDIGHLQEEL SSANGYPYRN
     SSLKRAQPSE QPQPGDAFKQ NLTQHVNRTF ESQGLAAPRR FAKIRYDFTA RNANELSVLK
     DEILEVLEDN KQWWKLLNRS GQAGYVPYNI LDVVKLEELE QVFNLRYKGD LSPRGYGPSS
     PTHKLPASYA GDKWGKLIHQ MDELNDELLK KITNNKIQPP QRNFRVEKPQ QVFVPLTFES
     STEEVKAWLE AKSFSKETVE HLGILTGAQL FSLNREELKK VCGDEGNRVY SKITVEKNQL
     ENNRGESELQ EIMKRRQERI DSA
//