ID A0A091I3M4_CALAN Unreviewed; 509 AA.
AC A0A091I3M4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Frizzled-2 {ECO:0000313|EMBL:KFP02015.1};
DE Flags: Fragment;
GN ORFNames=N300_11234 {ECO:0000313|EMBL:KFP02015.1};
OS Calypte anna (Anna's hummingbird) (Archilochus anna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC Trochilidae; Calypte.
OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP02015.1, ECO:0000313|Proteomes:UP000054308};
RN [1] {ECO:0000313|EMBL:KFP02015.1, ECO:0000313|Proteomes:UP000054308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP02015.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; KL218084; KFP02015.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091I3M4; -.
DR STRING; 9244.A0A091I3M4; -.
DR Proteomes; UP000054308; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd07458; CRD_FZ1_like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF34; FRIZZLED-2; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 2.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 2.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 2.
DR PROSITE; PS50038; FZ; 2.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..136
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 132..274
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 188..491
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 14..75
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 22..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 89..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 133..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP02015.1"
FT NON_TER 509
FT /evidence="ECO:0000313|EMBL:KFP02015.1"
SQ SEQUENCE 509 AA; 58196 MW; 8C7532F2AD3480EB CRC64;
HGEKGISIPD HGFCQPISIP LCTDIAYNQT IMPNLLGHTN QEDAGLEVHQ FYPLVKVQCS
AELKFFLCSM YAPVCTVLEQ AIPPCRSLCE RARQGCEALM NKFGFQWPER LRCENFPVHA
DHGFCQPISI PLCTDIAYNQ TIMPNLLGHT NQEDAGLEVH QFYPLVKVQC SLELKFFLCS
MYAPIRFARI WILIWSVLCC ASTFFTVTTY LVDMQRFRYP ERPIIFLSGC YTMVSVAYIA
GFVLEERVVC NERFQEDGYR TVVQGTKKEG CTILFMMLYF FSMASSIWWV ILSLTWFLAA
GMKWGHEAIE ANSQYFHLAA WAVPAVKTIT ILAMGQIDGD LLSGVCFVGL NNIDPLRGFV
LAPLFVYLFI GTSFLLAGFV SLFRIRTIMK HGGTKTEKLE RLMVRIGVFS VLYTVPATIV
IACYFYEQAF REHWERSWIS QNCKSLAIPC PLHFTPRMTP DFTVYMIKYL MTLIVGITSG
FWIWSGKTLH SWRKFYTRLT NSKQGETTV
//
