UniProt: A0A091IEJ4

Database: UniProt
Entry: A0A091IEJ4_CALAN

LinkDB:  A0A091IEJ4_CALAN 
Original site:  A0A091IEJ4_CALAN

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (2)   
   Pfam (1)   
   PROSITE (1)   
All databases (10)   

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ID   A0A091IEJ4_CALAN        Unreviewed;       534 AA.
AC   A0A091IEJ4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=tRNA (uracil-O(2)-)-methyltransferase {ECO:0000256|RuleBase:RU368004};
DE            EC=2.1.1.211 {ECO:0000256|RuleBase:RU368004};
DE   Flags: Fragment;
GN   ORFNames=N300_01790 {ECO:0000313|EMBL:KFP07024.1};
OS   Calypte anna (Anna's hummingbird) (Archilochus anna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC   Trochilidae; Calypte.
OX   NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP07024.1, ECO:0000313|Proteomes:UP000054308};
RN   [1] {ECO:0000313|EMBL:KFP07024.1, ECO:0000313|Proteomes:UP000054308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP07024.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-
CC       methyltransferase. {ECO:0000256|RuleBase:RU368004}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-
CC         methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43100, Rhea:RHEA-COMP:10339, Rhea:RHEA-COMP:10340,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; EC=2.1.1.211;
CC         Evidence={ECO:0000256|ARBA:ARBA00000660,
CC         ECO:0000256|RuleBase:RU368004};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU368004}.
CC   -!- SIMILARITY: Belongs to the TRM44 family.
CC       {ECO:0000256|ARBA:ARBA00009056, ECO:0000256|RuleBase:RU368004}.
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DR   EMBL; KL218617; KFP07024.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091IEJ4; -.
DR   STRING; 9244.A0A091IEJ4; -.
DR   Proteomes; UP000054308; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0141101; F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030488; P:tRNA methylation; IEA:UniProtKB-UniRule.
DR   InterPro; IPR011671; tRNA_uracil_MeTrfase.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR21210:SF0; TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR21210; UNCHARACTERIZED; 1.
DR   Pfam; PF07757; AdoMet_MTase; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU368004};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Methyltransferase {ECO:0000256|RuleBase:RU368004,
KW   ECO:0000313|EMBL:KFP07024.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368004};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU368004};
KW   tRNA processing {ECO:0000256|RuleBase:RU368004};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT   DOMAIN          490..520
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         490..520
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   REGION          339..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFP07024.1"
FT   NON_TER         534
FT                   /evidence="ECO:0000313|EMBL:KFP07024.1"
SQ   SEQUENCE   534 AA;  61748 MW;  F64B9F0AD6940BC2 CRC64;
     DVYNGTVTFL PLEENDEGKY QIKKCHIYQI QLTHIKDEEW SMSVVAPFPE DWLSDGITYP
     KLAWLGNELL SKLAKWSVEQ KPSEFKSTLS LISVAKYSQV YQDLKEKYKE IVKVWPEVTD
     PEKFVYEDVA IAAYLLILWE EERKEKGLTK KQSFVDLGCG NGLLVHILNN EGHSGRGIDV
     RRRKIWDMYG PETRLEESTI MPGDSHLFPD TDWLIGNHSD ELTPWIPVIA ARSSYSCCYF
     VLPCCFFDFH GKYIRRQSKK TQYREYLDFV VQVGSVCGFH VEEDCLRIPS TKKVCLIGKN
     RTYPPTESAL IDKQITQYLN NRPTCAVVTC NRRTGFNHKD QSDNVREGMG SELPENESTI
     WMPGFQPREK IEQIRNCSSL PRDFVDDVVL NVANLLLNEA PEKSYSNMHG GNTNTWNQGE
     SLSLREVAEQ LNKETLKRLK SEYGGLQTLL KNNHQVFKVL NGRVHIRDWR KEKPSRKTKP
     EVKRCLAAEA FKTRLCWFFI HHPDGCSLPS ELCPYAHGTE ELRESQIIKK KKHI
//

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