ID A0A091KDZ0_COLST Unreviewed; 863 AA.
AC A0A091KDZ0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Endothelial PAS domain-containing protein 1 {ECO:0000313|EMBL:KFP34313.1};
DE Flags: Fragment;
GN ORFNames=N325_03486 {ECO:0000313|EMBL:KFP34313.1};
OS Colius striatus (Speckled mousebird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coliiformes; Coliidae; Colius.
OX NCBI_TaxID=57412 {ECO:0000313|EMBL:KFP34313.1, ECO:0000313|Proteomes:UP000053615};
RN [1] {ECO:0000313|EMBL:KFP34313.1, ECO:0000313|Proteomes:UP000053615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N325 {ECO:0000313|EMBL:KFP34313.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK552909; KFP34313.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091KDZ0; -.
DR Proteomes; UP000053615; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd19728; bHLH-PAS_HIF2a_PASD2; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23043:SF8; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000053615};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 6..59
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 84..139
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 240..291
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 440..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 394
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 518
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 840
FT /note="(3S)-3-hydroxyasparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP34313.1"
FT NON_TER 863
FT /evidence="ECO:0000313|EMBL:KFP34313.1"
SQ SEQUENCE 863 AA; 96356 MW; 6102B33DAA607E0A CRC64;
RSSSERRKEK SRDAARCRRS KETEVFYELA HELPLPHNIS SHLDKASIMR LAISFLRTHK
LLSSVCADNE NELEADQQMD NLYLKALEGF IAVVTQDGDM IFLSENVNKY MGLTQVELTG
HSIFDFTHPC DHEEIRENLS LKNGPGFGKK SKEMSTERDF FMRMKCTVTN RGRTVNLKSA
TWKVLHCTGQ VKVYNTCPPH TLCGYKEPLL TCLIIMCEPI QHPSNIDIPL DSKTFLSRHS
MDMKFTYCDD RITELIGYHP EELLGRSAYE FYHALDSESM TKSHQNLCTK GQVVTGQYRL
LAKHGGYVWL ETQGTVIYNT RNLQPQCIVC VNYVLSEIEK NDVVFSMDQT ESLFKPHLLA
MGTAYKNSIP GPEQSDFLFT KLKEEPEELA QLAPTPGDAI ISLDFDTQKF EEAPAFPSAV
LTPNKPWPVE VKSHAAQGET LTVPSFTLPQ TAPGSSTPSA SSNSSCSTPS SPGDYYSSVD
EDLKIEMIEK LFAMDTESKS QCTSQTDFNE LDLETLAPYI PMDGEDFQLS PICQEEHPLS
ESAQNTQQSL SSMNTIFQPL TSASQNPLLP EKYCPQLSSN KNINPGHGSL SSVFFNNVSR
SSLPLYHDQA TTPLSSMGGR PNTQWPPDPP LQYVPAKWRL MDKYSGSLPS SSSGPPVHSA
SMPIYKKRPL DAFGQRGIDV NPARIALANS LKLKRQLDYE EQVLQQLTGG DPSVIHPSQL
MWKRMKFLKG ENCSLVTEKT SLSTSVLTDE FLCNSRGLSQ PMNQLQQQQQ QQQQQPPPTC
GSPGENLKTG AFPSPFYSCH YQDYTVQPAH KASGMASHLL GPSYEPYLLP KLTRYDCEVN
VPVLGSSALL QGNELLRALD QAT
//