ID A0A091KJA4_9GRUI Unreviewed; 2506 AA.
AC A0A091KJA4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Breast cancer type 2 susceptibility protein {ECO:0000313|EMBL:KFP39270.1};
GN ORFNames=N324_07302 {ECO:0000313|EMBL:KFP39270.1};
OS Chlamydotis macqueenii (Macqueen's bustard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis.
OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP39270.1, ECO:0000313|Proteomes:UP000053330};
RN [1] {ECO:0000313|EMBL:KFP39270.1, ECO:0000313|Proteomes:UP000053330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP39270.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK742701; KFP39270.1; -; Genomic_DNA.
DR Proteomes; UP000053330; Unassembled WGS sequence.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR002093; BRCA2_repeat.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF00634; BRCA2; 6.
DR PIRSF; PIRSF002397; BRCA2; 2.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR PROSITE; PS50138; BRCA2_REPEAT; 6.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000053330};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2447..2504
FT /note="Breast cancer type 2 susceptibility protein helical"
FT /evidence="ECO:0000259|Pfam:PF09169"
FT REGION 40..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1659..1682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2339..2402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2339..2353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2385..2400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2506 AA; 278789 MW; A8A322578B827A0B CRC64;
MAYKPVERPT FFEIFKARCS ESDLGPISLN WFEELSAEAP SYEPKSSEEL DGPVGWPDET
SFKTPGAKLS TYSQLPSTPQ IFKDENTILP PYSSPGKDLD QKKIGASREN LISPSITRRK
IDEENYILAS PPGTCHNCLA ASPAILRNIY QTPQRSNIPG PYGSLFCTPK LLEVRTPKRI
SESLGAEVDP DMSWSSSLAT PPTLGATVII ARENDSISGA KQQDERAETV LHNFFSNHDR
CSGTSDRSML SVPETVKLNA EDDIKDFESE MLDGLFGEIN IFEDTFNIPA KSSGTLQLMP
HALDAVEKCE INTDKAQGKE NFSSKQSIRR KTGISQEVKP TSWTEKSHSV EMEDSLLQNT
DEDTGDGKDG CLIGHKKELE SFKITGDVQD YRIHKSFENE KPVKEDIQFP SSQWSQLNLS
DLDVTHLEMS LCSSPPSDLS REENLEKSVL MTKDDAVETS LLNTSGLIKA QKLLSVNLSE
KCYEVKNSEK NPTSEITPVK SVSLSVQDPK LVKGCAAENV SKMSFLNCNS FLIESTNVTE
YSVVYNGSFS KHIKATSKSV VTDLLSHPLV CSATSPDNCN DLHLTNSENT LTKSDFKSLN
MLSSLRRRSK RFIYTINNAL LYQEEKIQKE VTSELPIHPL LPHLESGSCE FKGCHVARVD
EQDCLLFAER KHLQSNIEAN NFSTCTLKMD IMNNSSDNSF TDRLKQQDLR ALGENAREDQ
PATSLKCLKV SNTDKEDTTD SLNREIISNI KRKVLASACL MARKRSRLLP KGCCLEKREE
DKYVSANVDD GATVPWSLKE QLVCSLRDNE RFIDIHHDTT SVTNDGFNNT LSQIKFGING
ASSDCCNKIT TDKRHATGQW SVVDSKEVLG PLGINCSEND STGLKQGGKT DAAAFSEVVA
NNQEPKSVEN NESPQAAACN NVAVEIAKEL LDCIDDNSLN EVISEEDKQV APIYSSTKSK
ENLKYKGKSS GNLNACSLNL GFGGFQTASN KQIKLSEVSI AKGKMLFKDI ENECFEASSM
EKVRNISNQV KKENTFFSDS ESKLGSDLSD SLDLQASFLE RTHTQFIPHR AASCKRFPRS
QQCLQETNQM LTASQEAEIA ELSSILEETG SQFEFTQFRK QSNVVQNHAF QQFGTVETHG
TTNVENIPET RKDTDFCSTL KSENQVENDK YCTKQEETHE NSEVVEYEKE NAMVFHKNDK
KVTFTNLDRN ESRISDRSFP VAKQDHFSNF VGFTSAGGKK LNISKEALTR SAELFRDLDD
DNYLFVSSEN SARCRNSKGR MSSNCNFARS LTKENKGKTI CVSDFKSTGA ISHHAKKKNE
ENISTLFTKD TEHQTKRSVN YNENVNFSST IINSLSSIKK HNQNDKTSKQ VLNQGDCHVE
GSLHEDSLDV TCLGDGITAA EEHSLNISDE MENLSPNEKR EETKENEHLS QKLLAPAGGD
ISISDAALDH SLHLLNVPCG ERDVNVLENS DKQKTNHENM EGEDTTHDKN LLVNESRIKI
DSCHHHQIHF EQEENVEKDE VKGSYLTGFQ TASGKKITIA DGFLAKAEQF FAEDVDAGKA
HNDNSENPLK KRKCGKNCFK DCDLCIESIA QCDPEELNFN KNLVPGEPGD QFKQTVESSS
IKHTVIPHTV QTDTFVNLGE DCDRSLVTSY VRKKADIRPG KSELESIPEQ ESDALSRTHL
SEDGKLFAER EMEYSAKKRD DSENMHDFPV HSAASLHLRK VSNDLEDNSA PGDTKITSFV
EDSNNKSNQS LLLTSKSSSS NLKCDAKEFD LEHLNQPCAD RNCITDTVVN ACQKQLLVSL
PEDKTNLTSL KETSLNVDNQ KDDMKQTVFT TAKGKAVCVS ESALARVRQM FQEEYGESVK
YEIQTNSRTN QTEIAGNSPS VTHAKCPNSA KFLNATRSEE INSAASHYIE VHASVSENGH
QDANTFVDSK SVPNSQRQCF GQNVKLLGHL PVPAKQIKQS DSSAGSLGFF STASGKPVQL
SEESLRKARQ LFSEMEDNNS LHVQEALLVK EDVEKSEMHT EVVPRKMQIV LPEGEENAST
ELISDPAFGF STASGKRVAV SKNAYQKAKA ILKESDDFLS SGLCITDQLS AVKESGQCVK
SFTDKVISES KFEKSCNEES DLKSIYSEEM KSFPSTHHVK MPEYVPCSKK PNQSFGKEQL
NLGMKTESEA ISCSATAKAE TSVNLLQTPK HYLEVEAVES ARAFMEDDLS NSGVQISAAQ
SFSGKLDNNF QNKTFGKRHL EEKHSLGEPP IKRQLLLEFN RTKNPPRSLK ASKSTPDGIF
KDRRKFMYHV PLKPVTCQPF GATKERQEVK NPTLTLPDQD FKGFKSKPAI FQHCALRQSS
NGTSGVSTPC KASAKDSEET RSLHKSGKNV KTFIPPFKTK QTFSTGEKDS SKRCDSPISK
NTTEETELNQ IMTEQNIAEP QDHQSCSQHA ADTDLENGNL AMIKMIRNLH CARDLQEMRI
KKKYKQNISS QPGSLYVIKT SARNRISLKT AVEEKSPSFY STEEVH
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