ID   A0A091KJQ9_9GRUI        Unreviewed;       655 AA.
AC   A0A091KJQ9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   22-FEB-2023, entry version 42.
DE   SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KFP39703.1};
DE   Flags: Fragment;
GN   ORFNames=N324_08154 {ECO:0000313|EMBL:KFP39703.1};
OS   Chlamydotis macqueenii (Macqueen's bustard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis.
OX   NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP39703.1, ECO:0000313|Proteomes:UP000053330};
RN   [1] {ECO:0000313|EMBL:KFP39703.1, ECO:0000313|Proteomes:UP000053330}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP39703.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KK744202; KFP39703.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091KJQ9; -.
DR   Proteomes; UP000053330; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   PRINTS; PR00103; CAMPKINASE.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053330}.
FT   DOMAIN          1..94
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          133..278
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          416..653
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFP39703.1"
FT   NON_TER         655
FT                   /evidence="ECO:0000313|EMBL:KFP39703.1"
SQ   SEQUENCE   655 AA;  74750 MW;  D241519B6FF07A18 CRC64;
     VKRELAGVLI FESHPKAGTV LFNQGEEGTS WYIILKGSVN VVIYGKGVVC TLHEGDDFGK
     LALVNDAPRA ASIVLREDNC HFLRVDKEDF NRILRDVEAN TVRLKEHDQD VLVLEKIPAG
     NRISNQGNSQ PQHKYIVMSG TPEKILEHFL ETMRLEATLN EATDSVLNDF IMMHCVFMPN
     SQLCPALMAQ YPFHHGTYHA QPSQGTEQEK MDYALNNKRR VIRLVLQWAA LYGDLLQEDE
     AAMAFLEEFY VSVSDDTRMI AALKEQLPEL EKIVKQVSEE PKAPQKKHKV LLQLFNTSDD
     RAQKRQPIRG SDEVLFKVYC IDQTYTTIRV PVSSSVKEVI SAVADKLGSG EGLIIVKMSS
     GGEKVVLKPH DVSVFTTLSV NGRLFACPRD QFDSLAPLPE QEGPSTGTVG TFELMSSKDL
     AHQMTIYDWE LFNCVHELEL IYHTFGRHNF KKTTANLDLF LRRFNEIQFW VVTEICLCSQ
     LSKRVQLLKK YIKIAAHCKE YKNLNSFFAI IMGLSNVAVS RLSLTWEKLP SKFKKIYAEF
     ESLMDPSRNH RAYRLTVAKL EPPIIPFMPL LIKDMTFTHE GNKTFADNLV NFEKMRMIAN
     TVRTVKFCRS QSFNPDAALT NKNHQDVRSY VRQLNVIDNQ RTLSQMSHRL EPRRA
//