ID   A0A091KM44_9GRUI        Unreviewed;       861 AA.
AC   A0A091KM44;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
DE   Flags: Fragment;
GN   ORFNames=N324_12334 {ECO:0000313|EMBL:KFP40305.1};
OS   Chlamydotis macqueenii (Macqueen's bustard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis.
OX   NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP40305.1, ECO:0000313|Proteomes:UP000053330};
RN   [1] {ECO:0000313|EMBL:KFP40305.1, ECO:0000313|Proteomes:UP000053330}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP40305.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR601382-2};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC       {ECO:0000256|ARBA:ARBA00007658, ECO:0000256|RuleBase:RU361193}.
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DR   EMBL; KK746231; KFP40305.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091KM44; -.
DR   Proteomes; UP000053330; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd02126; PA_EDEM3_like; 1.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR044674; EDEM1/2/3.
DR   InterPro; IPR037322; EDEM3_PA.
DR   InterPro; IPR001382; Glyco_hydro_47.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR036026; Seven-hairpin_glycosidases.
DR   PANTHER; PTHR45679; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR45679:SF2; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3; 1.
DR   Pfam; PF01532; Glyco_hydro_47; 1.
DR   Pfam; PF02225; PA; 1.
DR   PRINTS; PR00747; GLYHDRLASE47.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF48225; Seven-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR601382-2};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycosidase {ECO:0000256|RuleBase:RU361193};
KW   Hydrolase {ECO:0000256|RuleBase:RU361193};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601382-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053330}.
FT   DOMAIN          617..704
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   REGION          735..837
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..798
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        811..835
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        75
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        222
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        316
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        334
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   BINDING         420
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFP40305.1"
FT   NON_TER         861
FT                   /evidence="ECO:0000313|EMBL:KFP40305.1"
SQ   SEQUENCE   861 AA;  96565 MW;  D3A7C66049D7C7E3 CRC64;
     YPADELMPLT CRGRVRGQEP SRGDVDDALG KFSLTLIDTL DTLVVLNKTK EFEEAVKKVI
     KDVNLDNDIV VSVFETNIRV LGGLLGGHSV AIMLKEKGEY MQWYNGELLR MAKELGYKLL
     PAFNTTSGLP YPRVNLKFGV RHPEARTGTE TDTCTACAGT LILEFAALSR FTGTSIFEEY
     ARKALDFIWE KRQRSSNLVG VTINIHTGDW VRKDSGVGAG IDSYYEYLLK AYVLLGDDSF
     LERFNTHYDA IMRYISQPPL LLDVHIHKPM LNARTWMDSL LAFFPGLQVL KGDIRPAIET
     HEMLYQVIKK HNFLPEAFTT DFRVHWAQHP LRPEFAESTY FLYKATGDPY YLEVGKTLIE
     NLNKYARVPC GFAAMKDVRT GSHEDRMDSF FLAEMFKYLY LLFADKEDMI FDIEDYIFTT
     EAHLLPLWLS TTNQTISKKN TTTEYTELDD SNFDWTCPNT QILFPNDPMF AQSIREPLKN
     VVDKSCPRGI SRAEESFGSG PKPPLRARDF MASNPEHLEI LKKMGVSLIH LKDGRVQLVQ
     HAVQAASSLD AEDGLRFMQE MIELSSQQQK EQQLPPRAVQ IVSHPFFGRV VLTAGPAQFG
     MDLSKHKAGT RGFVATIKPY NGCSEITNPE AVKEKIALMQ RGQCMFAEKA RNIQKAGAIG
     GIVIDDNEGS SSDTAPLFQM AGDGKNTDDI TIPMLFLFNK EGNIILDAIR EYEAVEVLLS
     DKAKDRDLEV ENMDQKLSEN DSHKQSSEEA ASASQDAGAI SEEPEEGESP DVPDPDSLSP
     AHADSDSVSI SNQDSYVPGT EAAPAPEPAC TQEDNQPQEL KTETESNSKV NWDNKAQPME
     SILADWSEDI EAFEMMEKDE L
//