ID A0A091KN38_COLST Unreviewed; 522 AA.
AC A0A091KN38;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Rho guanine nucleotide exchange factor 3 {ECO:0000256|ARBA:ARBA00023847};
GN ORFNames=N325_08194 {ECO:0000313|EMBL:KFP29204.1};
OS Colius striatus (Speckled mousebird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coliiformes; Coliidae; Colius.
OX NCBI_TaxID=57412 {ECO:0000313|EMBL:KFP29204.1, ECO:0000313|Proteomes:UP000053615};
RN [1] {ECO:0000313|EMBL:KFP29204.1, ECO:0000313|Proteomes:UP000053615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N325 {ECO:0000313|EMBL:KFP29204.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA
CC and RhoB GTPases. {ECO:0000256|ARBA:ARBA00043905}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KK535164; KFP29204.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091KN38; -.
DR Proteomes; UP000053615; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd10572; PH_RhoGEF3_XPLN; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR044129; PH_RhoGEF3_XPLN.
DR PANTHER; PTHR46006:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053615}.
FT DOMAIN 120..302
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 332..447
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 74..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 60116 MW; CE7C503F63DD751B CRC64;
MVAKDYPFYL SVKRANCALE VQTVSSPAKE TEEPSNKRVK PLSRVTSLAS LLPPVRATPY
SSIYFQRSIS FRSDSRPDLL SPRPWSRNMP PANTKRRDSK LWSETFDVCV NHMLTSKEIK
RQEAIFELSQ GEEDLIEDLK LAKKAYHDPM LKLSIMTEQE LNQIFGTLDS LIPLHEDLLR
RLKEVRKPDG STEHVGHILV GWLPCLNSYD SYCSNQVAAK ALLDHKKQDH RVQDFLQRCL
ESPFSRKLDL WNFLDIPRSR LVKYPLLLRE ILRHTPNDHR DQQHLEEAIN IIQGIVAEIN
IKTGESECQY YKERLIYLEE GQRDSLIDNS RVVCCHGELK NNRGVKLHVF LFEEVLVITR
AVTHNEQLCY QLYRQPIPVR ELMLEDLQDG EVRLGGSIRG AFSNNERIKN FFRVSFKNGS
QSQTHSLQAN DSFSKQQWLN CIRQAKEKVT CAGKAGVLSS EAHFLLSPNG SRVPQRETTL
EQMDQSDCES DCSMDTSEIS TDCERMEQTN SCENEKQIET NV
//
