ID A0A091LAK0_CATAU Unreviewed; 925 AA.
AC A0A091LAK0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 {ECO:0000313|EMBL:KFP52917.1};
GN ORFNames=N323_01906 {ECO:0000313|EMBL:KFP52917.1};
OS Cathartes aura (Turkey vulture) (Vultur aura).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Cathartidae; Cathartes.
OX NCBI_TaxID=43455 {ECO:0000313|EMBL:KFP52917.1, ECO:0000313|Proteomes:UP000053745};
RN [1] {ECO:0000313|EMBL:KFP52917.1, ECO:0000313|Proteomes:UP000053745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N323 {ECO:0000313|EMBL:KFP52917.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00010594}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL310128; KFP52917.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091LAK0; -.
DR Proteomes; UP000053745; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF21; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 2; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF01033; Somatomedin_B; 2.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 2.
DR PROSITE; PS50958; SMB_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 55..98
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 99..143
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REGION 318..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..363
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 105976 MW; 457826CA7B5A80E1 CRC64;
MAKKGCVHSH QVISLFAFAF GVNVCMGFTT NRFRRSEEWD EGPVSVLSDS PWISTSGSCK
NRCFELQEAE PPGCRCDNLC KSYNSCCFDF DELCLKTARG WECTKDRCGE TRNDDNACHC
SEDCLSRGDC CTNYQVVCKG ETHWVDDDCE EIKAPECPAG FVRPPLIIFS VDGFRASYMK
KGNKVMPNIE KLRSCGTHSP YMRPVYPTKT FPNLYTLATG LYPESHGIVG NSMYDPVFDA
SFSLRGREKF NHRWWGGQPI WITAAKQGVK AGTFFWSVVI PHERRILTIL QWLTLPDNER
PYVYAFYSEQ PDAAGHRYGP FNSEESSYGS PLTPPKRPKR KLPPKRRQER PVAAPKKRRR
KVHRVDQYAA EARRKKMMVN PLREIDKTVG QLMDGLKQLK LHRCVNVIFV GDHGMEDTTC
ERTEFLSNYL TNVEDIILLP GSLGRIRPRS SNNLKYDPKV IVANLTCRKP DQHFKPYLKQ
HLPKRLHYAY NRRIEDVHLL VDRKWHVARK AVDVYKKPTG KCFFHGDHGY DNKINSMQTV
FIGYGPTFKY KTKVPPFENI ELYNVMCDLL GLKPAPNNGT HGSLNHLLRA NVYKPTVPDE
VAKPLYPVAL PSASDFDIGC TCDDKVVILI LFLFSILEKN KLDELNKRFH VKGTEEKHLL
YGRPAVLYRT KYNILHHHDF ESGYSETFLM PLWTSYTISK QAEVSGVPEH LASCVRPDLR
ISPGNSQSCA AYRGDKQLSY GFLFPPQLSS SAEAKYDAFL ITNIIPMYPA FKKVWNYFQR
VLVKRYATER NGVNVISGPI FDYDYDGLHD TPDKIKQFVE GSAIPVPTHY YAIITSCLDF
TQPADKCDGP LSVLSYILPH RPDNDESCNS LEDESKWVED LLKMHTARVR DIEQLTSLDF
FRKTSRSYTE ILSLKTYLHT FESEI
//
