ID A0A091LKX7_CATAU Unreviewed; 713 AA.
AC A0A091LKX7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=DNA mismatch repair protein Mlh1 {ECO:0000313|EMBL:KFP56859.1};
DE Flags: Fragment;
GN ORFNames=N323_05813 {ECO:0000313|EMBL:KFP56859.1};
OS Cathartes aura (Turkey vulture) (Vultur aura).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Cathartidae; Cathartes.
OX NCBI_TaxID=43455 {ECO:0000313|EMBL:KFP56859.1, ECO:0000313|Proteomes:UP000053745};
RN [1] {ECO:0000313|EMBL:KFP56859.1, ECO:0000313|Proteomes:UP000053745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N323 {ECO:0000313|EMBL:KFP56859.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KL327665; KFP56859.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091LKX7; -.
DR Proteomes; UP000053745; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053745}.
FT DOMAIN 177..296
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 408..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP56859.1"
FT NON_TER 713
FT /evidence="ECO:0000313|EMBL:KFP56859.1"
SQ SEQUENCE 713 AA; 79921 MW; 1AF02B804F7A1515 CRC64;
LDAKSTSIQV VVKEGGLKLI QVQDNGCGIR KEDLDIVCER FTTSKLQKFE DLASISTYGF
RGEALASISH VAHVTVTTKT ADAKCAYRAT YSDGKIKAPP KPCAGNQGTQ ITVEDLFYNV
NTRRKALKNP NEEYAKILEV VSRYAIHNSG ISFSVKKQGD TVSDVRTLSN TSTVDNIRSI
FGNAVSRELI EVGCEDASLA FKMKGYITNA NYSVKKCIFL LFINHRLVES AALRKAIETV
YAAYLPKSTH PFLYLSLEIA PQNVDVNVHP TKHEVHFLHE DSILERVQQH VESKLLGSNS
SRMYFTQTLL PGADCSSSEV VKASANSSAA SKGTSDKVYA HQMVRTDSRE QKLDAFLQPV
NNPLSTGPTE AMTEVNVGPP EGVVRPQDAE MEDVSDLVEI ADVQENTVMP GGLSESGHVS
PETVPPRKRP REDVDIEMEK DDTRKDMTAA CTPRRRIINL TSVLTLQEEI SNQAHANLQE
MLHDHSFVGC VSPQWALAQY QTKLYLLNTT KLSQELFYQI LIYDFANFGV LRLSEPAPLY
ELSMLALEDP ESGWTEEDGP KEGLAEYIVE FLKKKTEMLK DYFSLEIDEE GNLIGLPLLI
DNYVPPLEGL PMFILRLATE VNWDEEKECF ESLSKELAMF YSIRKQYIID EANLTNSQNE
DSDSGSTTWK WTVEHVLYKA FRTHLLPPKH FTEDGNILQL ANLPDLYKVF ERC
//
