ID A0A091MCR9_9PASS Unreviewed; 1090 AA.
AC A0A091MCR9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 45.
DE SubName: Full=Son of sevenless 2 {ECO:0000313|EMBL:KFP71680.1};
DE Flags: Fragment;
GN ORFNames=N310_02425 {ECO:0000313|EMBL:KFP71680.1};
OS Acanthisitta chloris (rifleman).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Acanthisittidae;
OC Acanthisitta.
OX NCBI_TaxID=57068 {ECO:0000313|EMBL:KFP71680.1, ECO:0000313|Proteomes:UP000053537};
RN [1] {ECO:0000313|EMBL:KFP71680.1, ECO:0000313|Proteomes:UP000053537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N310 {ECO:0000313|EMBL:KFP71680.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK823805; KFP71680.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091MCR9; -.
DR Proteomes; UP000053537; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053537}.
FT DOMAIN 128..319
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 372..475
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 522..667
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 705..944
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 945..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1060..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP71680.1"
FT NON_TER 1090
FT /evidence="ECO:0000313|EMBL:KFP71680.1"
SQ SEQUENCE 1090 AA; 126067 MW; C2B2CD08CE939E70 CRC64;
QERVQKTFPH PIDKWAIADA QCAIEKKKRR NPLLLPVDKI HPLLKEVLGY KVDYHVSLYI
VAVLEYISAD ILKLAGNYVF NIRHFEISQQ DIKVSMCADK VLMDMFDQDE IGLVSLCEDE
PSSSGELNYY DLVRNEIAEE RQYLRELNLI IKVFREAFLS NSKLFTPTDI DVIFSNISDI
HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI LSPQFHEHFN
NLMAKPAVAL HFQSTAEGFK EAVQYVLPRL MLIPVYHCLH YFDLLQLLER RLEPVKEDRE
CLKQAITALL NLQCSMERIY SKHSPRRRPG EPVCRFYHRQ VRSKHLAIKK MNEIQKNIDG
WEGKDIGQCC NEFIMEGGLT KIGAKHERHI FLFDGLMISC KTNHGQSRLP GYSSAEYRLK
EKIIMRKIQI IDREDTSEYK HAFELVSKDD NSILFAAKSA EEKSNWMAAL ISLQYRSTLD
RMLDSVLLQE ENEQPLRLPS PNVYRFVVED SEENSKDLQD KKIFAMKSPG TVVKLIERLT
YHMYADPNFV RTFLTTYRSF CKPQELLSLL IERFEIPEPE PTEADRLAIE KGEQPISADL
KRFRKEYVQP VQLRILNVFR HWVEHHFYDF ERDLELLERL ETFISSVRGK SMKKWVVSIA
KIIKRKKAQA NGISHNITFE SPPPPIEWHI WRVGHSEALD LMTLHPIEIA RQLTLLESDL
YRAVQPSELV GSVWTKEDKE INSPNLLKMI RHTTNLTLWF EKCIVETENF EERVAVLSRI
IEILQVFQDL NNFNGVLEIV SAMNSVSVYR LDHTFEALQE RKKRVLDEAV ELSQDHFKKY
LAKLKSINPP CVPFFGIYLT NILKTEEGNP DFLKRQGKEL INFSKRRKVA EITGEIQQYQ
NQPYCLRIEP EIRKFFENLN PMGKIPEKEF TDYLFNKSLE IEPRNCKQPP RFPRKTTYPL
KSPGIRPNAG RHGSTSGTLR SHPLPLEKEP SKISFSSITE AEHESTVSAP TSPNTPSTPP
VSASSEFSVF LDIDLNSSYG NNSIFAPVNL PQSKTFFSSW GSFPKLSDEP QNPPPLPPRK
KMDQDVSNAK
//
