ID A0A091MJI5_9PASS Unreviewed; 873 AA.
AC A0A091MJI5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=[heparan sulfate]-glucosamine N-sulfotransferase {ECO:0000256|ARBA:ARBA00012979};
DE EC=2.8.2.8 {ECO:0000256|ARBA:ARBA00012979};
GN ORFNames=N310_06301 {ECO:0000313|EMBL:KFP73947.1};
OS Acanthisitta chloris (rifleman).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Acanthisittidae;
OC Acanthisitta.
OX NCBI_TaxID=57068 {ECO:0000313|EMBL:KFP73947.1, ECO:0000313|Proteomes:UP000053537};
RN [1] {ECO:0000313|EMBL:KFP73947.1, ECO:0000313|Proteomes:UP000053537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N310 {ECO:0000313|EMBL:KFP73947.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
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DR EMBL; KK827569; KFP73947.1; -; Genomic_DNA.
DR RefSeq; XP_009082805.1; XM_009084557.1.
DR AlphaFoldDB; A0A091MJI5; -.
DR GeneID; 103811573; -.
DR KEGG; achl:103811573; -.
DR CTD; 9348; -.
DR OrthoDB; 2913264at2759; -.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000053537; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019213; F:deacetylase activity; IEA:UniProt.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF29; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 3; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053537};
KW Transferase {ECO:0000313|EMBL:KFP73947.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..506
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 596..844
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 605
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 703
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 808
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 824..828
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 809..819
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 873 AA; 100837 MW; 0BBD64BFC9AC55EA CRC64;
MSFILKLHRH FQRTVILLAT FCMVSIVISA YYLYNGYKQE NELPEISSEV ECGDPQLLPY
KLMEMKTVKP IDPLRTDLVV LVFVESQYST LGQDIITILE SSRFQFHIEI APGKGDLPVL
IDKNRGKYAL IVYENILKYV NMDSWNRGLL DKYCIEYGVG VIGFHKGSEN SLQSFQLKGF
PFHVHSNLGI KDCCINPHSP LLHVTKSSKL EKGPLLGNDW AVFQINHTAY QPVIFAKVKA
PENLSPPAAL GALYATVIHD LGLHDGIQRV LFGNNLNFWL HKLIFIDAIS FLSGKKLRLS
LDRYILVDID DIFVGKEGTR MNTNDVQALL DTQNLLRAQI TNFTFNLGYS GKFYHTGTEE
EDEGDDLLLR SVDEFWWFPH MWSHMQPHLF HNESSLVEQM ILNKKFALEH GIPTDLGYAV
APHHSGVYPV HVQLYDAWKK VWNIRVTSTE EYPHLKPARY RRGFIHKNIM VLPRQTCGLF
THTIFYKEYP GGPKELDKSI QGGELFFTVV LNPISIFMTH LSNYGNDRLG LYTFVNLANF
VHTWTNLKLQ TLPPVQLAHK YFELFPEQKD PLWQNPCDDK RHRDIWSKEK TCDRLPKFLV
VGPQKTGTTA LYLFLIMHPS IISNSPSPKT FEEVQFFNRN NYHRGIDWYM DFFPTPSNIT
TDLLFEKSAN YFHSEEAPKR AASLIPKAKI ITILIDPSDR AYSWYQHQRS HEDPAALKFS
FYQVITAGPR APAELRALQK RCLAPGWYAT HIERWLTYFP PYQLLIIDGQ QLRTDPSTVM
DEVQKFLGVS PHYNYSEALT FDSHKGFWCQ LLEEGKTKCL GKSKGRKYPP MDSECRAFLS
SYYRDHNVEL SKLLHKLGQP LPSWLRQELQ KVR
//
