ID A0A091NY28_HALAL Unreviewed; 534 AA.
AC A0A091NY28;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00013303};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Acid beta-galactosidase {ECO:0000256|ARBA:ARBA00031635};
DE Flags: Fragment;
GN ORFNames=N329_01472 {ECO:0000313|EMBL:KFP98171.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFP98171.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFP98171.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFP98171.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cleaves beta-linked terminal galactosyl residues from
CC gangliosides, glycoproteins, and glycosaminoglycans.
CC {ECO:0000256|ARBA:ARBA00002691}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809}.
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DR EMBL; KK644776; KFP98171.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091NY28; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR019801; Glyco_hydro_35_CS.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421:SF172; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379}.
FT DOMAIN 1..270
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 317..429
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 458..518
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 102
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 182
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP98171.1"
FT NON_TER 534
FT /evidence="ECO:0000313|EMBL:KFP98171.1"
SQ SEQUENCE 534 AA; 59823 MW; 29D0C2887096D33B CRC64;
YVPWNYHEPQ VDMYDFSGDK DLEYFLQLAN DTGLLVILRA GPYICAEWDM VQPFVTVTSF
LGSSDSDYLA AVEKWMGVLL PKMRPHLYQN GGPIIMVQVE NEYGSYFACD YDYLRSLLKL
FRQYLGDEVV LFTTDGASQF HLKCGALQGL YATVDFAPGG NVTAAFLAQR GSEPTGPLVN
SEFYTGWLDH WGHRHSVVPA QTIAKTLNEI LAHGANVNLY MFIGGTNFAY WNGANMPYMP
QPTSYDYDAP LSEAGDLTEK YFALREVIGM YKQLPEGLIP PTTPKFAYGK VRLQKVGTVV
EALDRLSPAG PVKSTYPLTF VQLKQYFGFV LYRTTLPKNC TEPTQLSSPL NGVHDRAYVS
VDGVPQGVLE RDKSLMINIT GKAGTNLDIL VENMGRVNFG RYNNDFKGLV SNLTLDQDIL
VEWEIYPLDI DGAVNHDINS HLYRPKRSVG NPLSYEAPTF YTGRLSIPGG IPDLPQDTYV
KFPGWTKGQI WINGFNLGRY WPARGPQLTL YVPRNILVSS VPNNITVLEL ERSP
//
