ID   A0A091P159_HALAL        Unreviewed;      1180 AA.
AC   A0A091P159;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=N329_03105 {ECO:0000313|EMBL:KFQ00840.1};
OS   Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC   Accipitrinae; Haliaeetus.
OX   NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ00840.1, ECO:0000313|Proteomes:UP000054379};
RN   [1] {ECO:0000313|EMBL:KFQ00840.1, ECO:0000313|Proteomes:UP000054379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ00840.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR   EMBL; KK649287; KFQ00840.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091P159; -.
DR   Proteomes; UP000054379; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd12882; SPRY_RNF123; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR045129; RNF123/RSPRY1-like.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035773; SPRY_RNF123.
DR   PANTHER; PTHR13363:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF123; 1.
DR   PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054379}.
FT   DOMAIN          75..255
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          729..753
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1180 AA;  133668 MW;  DA825BB512181309 CRC64;
     MTSRGAGTTF SRKNYRLSTE PEKSKVTGIV NSRLLNDYLH RVFTNADGNQ PAAAYRKHLT
     FQNLQEHLDR LLAEENGSED SRDQVVEGRL GPSTVVLDHT SGFEGLLLVD DDLLGVIGHS
     NFGSIRATTC VYKGKWIYEV LISSQGLMQI GWCTLNCRFN QEEGVGDTPD SYAYDGNRVR
     KWNVTTTNYG KSWAAGDIVS CLIDLEEGTI AFCLNGISLG TAFDNITRGA GMAYFPAISL
     SFKESVAFNF GSRPLRYPLV EGYRPLQDAP VADLVKARKL LGYLKNVIHI GIDVTEGKLV
     EKDTSMWQLQ GEPTVLITLA HIFNYFSPLM CKVYLVEDVL MTFLLSILER GGAVEAHPLI
     QQLLDLMWLL MEEYEVHECL KQLLMSLLRA YRFSPIIPDL GLQIHYLRLT IAVLKHEKSR
     KYLLSNVLFD VLRSVVFFYI KSPLRVEEAG LQELIPTTWW PNRFTKEGKE SKEAKEESAE
     ERLRRRAYER GCQRLKKRIE VVEGLQVQIL KLLLNNKDRG GGEASRYIFL NKFRKFLQEN
     ASNRGNLTVL CPPEYMVCFL HRLIAALRFF WDGHKAKTPA ALSSEEAYVP PQLFYNGKVD
     YFDLQRLGGL LSHLKKTLKG KCSHFQYLHP DDLAAKANVL IDPAELQAVT MDDLDEDEES
     ATSAAQSQRP SAALAIGGAL ARPGWLSSPT LGRANRFLST AAVSLMNPRR PLGTLEKIKV
     RTLSVEQRTE EDIEGSHGNE GLLLGRPPEE PEQPITENSL LEVLDGIVMM YNLSVHQQLG
     KMVGVSDDVN EYAMALKDTE EKISRCPKRR RDIHEELLKS QKVFSEKLNH LSRRLAWINV
     TIYSKEKMQD VYWLLRVCIR TIEHGDRTGS LFAFMPEFYL SVAMNSYSAL KNYFSPVNSM
     EELPGYEETL MRLAAILAKH FADSRIVGTD IRDSLMQALA SYVCYPHSLR AVERIPEDQR
     ISMMKNLLAP YEQRPWAQTN WILVRLWRGC GFGYRYTRLP HLLKTKPEDA SLPSLQKPCP
     STLLQRHMAD LLRSDRDLAP SFLNSVLNQL NWAFSEFIGM IQEIQQAAER LERNFVDSRQ
     LKVCATCFDL SVSLLRVLEM TVTLAPEIFL DWNRPSSELL LRRLAQVLSF MQPCSACHEV
     AVALSFSFAS IGLESVDHYP ILVAVTGILV RLLVDTDVQG
//