ID A0A091PES3_LEPDC Unreviewed; 705 AA.
AC A0A091PES3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 28.
DE SubName: Full=Protein-glutamine gamma-glutamyltransferase 6 {ECO:0000313|EMBL:KFQ05866.1};
DE Flags: Fragment;
GN ORFNames=N330_10332 {ECO:0000313|EMBL:KFQ05866.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ05866.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ05866.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ05866.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; KK672149; KFQ05866.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PES3; -.
DR PhylomeDB; A0A091PES3; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF50; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 6; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW Transferase {ECO:0000313|EMBL:KFQ05866.1}.
FT DOMAIN 265..357
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 273
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 331
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 354
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 394
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 396
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 443
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 448
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ05866.1"
FT NON_TER 705
FT /evidence="ECO:0000313|EMBL:KFQ05866.1"
SQ SEQUENCE 705 AA; 79570 MW; CDB4CA4E13EB1DF7 CRC64;
FLALKIANVN WQSKLNKAAH HTSDYSSTEA ILRRGQPFNI TLNLQTTVQP GDNFTFIAST
GPCPAESQQT KAVFNLLEED ASGWSATQEP SEPGCMNFTI FSPANAVIGR YKLKLQIVSG
NKVSSTLLGQ FVLLFNPWCP NDDVYMANEK ERQEYVLNDS GIIFQGLEKY IQQEAWNYGQ
FEEDILDISL AILDRSLNHR QDPAVDVSNR NNPIYVSRVV SAMVNSNDEK GVVEGKWNGN
YCSGTNPLQW SGSVTILRKW YRGRYKPVRY GQCWVFAGVM CTVLRSLGIP TRVITNFNSA
HDRNINLSID NYIDISGKTL HLTEDSVWNF HVWNESWFIR RDLGSFYDGW QVLDATPQER
SKGIYRCGPA STRAIKEGDV NLDYDSSFLF AAVNADYVTW IHYSNKRKER IYSDSRKIGK
FISTKAVGTN CRVDVTANYK YPEGSLKERQ VYKKARKLLG VRSTGKRTKI ARPRRRSSVA
WRQNMAQPAQ KPSISAKLIL DAPPVIGQDI LFTLALRNLI SDFKTIKVKL RASAILYTRK
PKAEILQLSR SIKLGSEEVK EISFKISYSQ YKNSLKDDRK ILVTAVCETT QEASLLVEKD
IVLQDPFLTI EVLGPTVVHK AVNVQVTLTN PLSEVVTDCE LRAEGSGLLK EQLRINVARM
APMESLTVQF EIIPYKSGTR LLQVDFVCIH FSDIKGFVML DVAPA
//
