ID A0A091PVT6_HALAL Unreviewed; 515 AA.
AC A0A091PVT6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Rho guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KFQ01088.1};
DE Flags: Fragment;
GN ORFNames=N329_05305 {ECO:0000313|EMBL:KFQ01088.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ01088.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ01088.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ01088.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK649693; KFQ01088.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PVT6; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11973; SH3_ASEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 11..70
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 107..291
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 322..429
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 78..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ01088.1"
FT NON_TER 515
FT /evidence="ECO:0000313|EMBL:KFQ01088.1"
SQ SEQUENCE 515 AA; 60747 MW; 8B218D31B5DDEB1F CRC64;
ELLCPQLISD GSVVYAEALW DHVTMDDQEL GFKAGDVIEV MDATNKEWWW GRILDSEGWF
PASFVRLRVN QDEPMEDYPL KVEGGKEDDS SSGTRRFGMG QTTKDQMRTN VINEIISTER
DYIKHLKDIC EGYIKQCRKR ADMFTEEQLK TIFGNIEDIY RCQKKFVKAL EKKFNKDHPH
LSEVGSCFLE YQTEFQIYSE YCNNHPNACM ELSRLTKVNK YVYFFEACRL LQKMIDISLD
GFLLTPVQKI CKYPLQLAEL LKYTNPQHRD FKDVEAALNA MKNVARLINE RKRRLENIDK
IAQWQSSIED WEGEDVLVRS SELIYSGELT KISHPQAKSQ QRMFFLFDHQ LVCCKKDLLR
RDILYYKSRI NMDDMEIVDV EDGKDKDFNL SVKNAFKLHC QDTEEVHLFC AKKPEQKQRW
LKAFENERRQ VQLDQETGFS ITEVQKKQAM LNASKQHHTG KPKAVTRPYY DFLMRQKHPT
LPTTLPQQQV FMLAEPKRKP SNFWQNISRL TPFRK
//
