ID A0A091PZC4_LEPDC Unreviewed; 744 AA.
AC A0A091PZC4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=ARF GTPase-activating protein GIT2 {ECO:0000313|EMBL:KFQ12626.1};
DE Flags: Fragment;
GN ORFNames=N330_12693 {ECO:0000313|EMBL:KFQ12626.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ12626.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ12626.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ12626.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK681075; KFQ12626.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PZC4; -.
DR PhylomeDB; A0A091PZC4; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF4; ARF GTPASE-ACTIVATING PROTEIN GIT2; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..111
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 153..185
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 365..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 431..465
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 395..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ12626.1"
FT NON_TER 744
FT /evidence="ECO:0000313|EMBL:KFQ12626.1"
SQ SEQUENCE 744 AA; 83024 MW; 25C94DFABC58811B CRC64;
CSFSDPCWAS INRGILICDE CCSVHRSLGR HISQVRHLKH TPWPPTLLQM VETLYNNGAN
SIWEHSLLDP ASVMSGRRKA SPQDKVHPNK AEFIRAKYQM LAFVHRLPCR EDDSVTAKDL
SKQLHSSVRT GNLETCLRLL SLGAQANFFH PEKGNTPLHV AAKAGQTLQA ELLAVYGADP
GTQDSNGKTP VDYARQGGHH ELAERLVEIQ YELTDRLAFY LCGRKPEHKN GQHFVIPQMA
DSSLDLSELA KAAKKKLQSL SNHLFEELAM DVYDEVDRRE TDAVWLATQN HSTLVTETTV
VPFLPVNPEY SSTRNQGRQK LARFNAHEFA TLVIDILSDA KRRQQGNPLT GSKENVELIL
KSISNQHSSE SQDNDQPDYD SVASDEDTDL ETNAAKSNRQ KSLDSDLSDG PVTAQEYMQV
KNALVASEVK IQQLMKVNIN LSDELRVMQK KLQTLQSENT NLRRQATTNI YQVQSGSEYT
DPTNNSSLKR RPSARGSRPM SMYETGSGQK PYLPMGEVPY PEESITRLQP FPPHIGRSAF
VTSSSSLPSF PSTLSWSRDE STRRASKLEK QSSVSESDYD NPTAPLELEE TGSGRKGRQR
SVIWQGEGSI PEDADAAPSS SLPSTEDVIR KTEQITKNIQ ELLRAAQENK HDSYIPCSER
IHVAVTEMAA LFPKKPKSEL VRTSLRLLTS SAYRLQSECK KTLPVETCPT TDIQLVTQQV
IQCAYDIAKA AKQLVTITTK ENNN
//
