ID A0A091Q2S4_LEPDC Unreviewed; 851 AA.
AC A0A091Q2S4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA replication ATP-dependent helicase/nuclease DNA2 {ECO:0000256|ARBA:ARBA00021516};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=DNA replication ATP-dependent helicase-like homolog {ECO:0000256|ARBA:ARBA00032548};
DE Flags: Fragment;
GN ORFNames=N330_08140 {ECO:0000313|EMBL:KFQ14220.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ14220.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ14220.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ14220.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; KK685011; KFQ14220.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091Q2S4; -.
DR PhylomeDB; A0A091Q2S4; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017116; F:single-stranded DNA helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:UniProtKB-UniRule.
DR CDD; cd18041; DEXXQc_DNA2; 1.
DR CDD; cd22318; DNA2_N-like; 1.
DR Gene3D; 2.40.30.270; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR026851; Dna2/JHS1_DEXXQ-box.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR048459; DNA2_Rift.
DR InterPro; IPR014808; DNA_replication_fac_Dna2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR PANTHER; PTHR36531; CRISPR-ASSOCIATED EXONUCLEASE CAS4; 1.
DR PANTHER; PTHR36531:SF6; DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF08696; Dna2; 1.
DR Pfam; PF21123; Dna2_Rift; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Helicase {ECO:0000313|EMBL:KFQ14220.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001}.
FT DOMAIN 36..242
FT /note="DNA replication factor Dna2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08696"
FT DOMAIN 431..527
FT /note="DNA2 rift barrel"
FT /evidence="ECO:0000259|Pfam:PF21123"
FT DOMAIN 587..683
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 688..754
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 763..850
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ14220.1"
FT NON_TER 851
FT /evidence="ECO:0000313|EMBL:KFQ14220.1"
SQ SEQUENCE 851 AA; 96269 MW; FB242C64E77ADB35 CRC64;
LRNGLNNRYR VLEVSIIQRN RSDPEKHLSI TASQSLENTE LCILRNGWES VPVVPGDIIH
LEGECNSGTW VINEQSGYLV LYPDLLLSGT TISNSIRCTR RAVLSERFRG SESGSRQTLV
GTILHEIFQQ SVTNYLAQEK VEELANKIVY GQKYLKEMYH LNLKQTEIMQ EVEEYLPSFF
KWMEDFMHNP ANRNKMQLKL SSAEKTEDLS SKIEIVDILN IEENIWSPRF GLKGKIDVTA
RVKIYCRSGV QSRIMPLELK SGKESNSIEH RSQVILYTLL NLERRVDPEA GFLLYLKTGT
MYPVSGARMD RRELMKLRNH VAFYLTHSTY KSAVGGQHSQ LAALPPVIDD SQACKHCSQI
HNCFLYNRAV EQKMANVSFP PAMVPIIERE TQHLKPSHLE YFSLWYLMLT LELQSGEGKK
GYKNIWMIPS LEREKAGDCV GNMIRVDEVQ EISEGQYLHF FQRRNGAIPG TNLLVGDRVV
VSGEENGLLG LATGYVREVS VMKVSCLLGR NLSKLPKNTI FRLDHEEGDF GIGVPFENLS
KLMKDSPVSE RLRNLIIDFH KPCFIQHLSS VLPPEAKETV ANILKGLNKP QKQAMKKVLL
SKDYTLIVGM PGTGKTTTIC ALVRILSACG FSVLLTSFTH TAVDNVLLKL AKFKVGFLRL
GRAQKVHPDI QKFTEEEICR SKSVTDLEEV YNSQPVVATS CMGINHPIFV RKQFDFCIVD
EASQISQLTC LGPLFCSKRF VLVGDHEQLP PLVLNAEARD LGMSESLFKR LERNQNAVVQ
LTVQYRMNSK IMSLSNMLVY EGKLECGSEK VSNATVNLPN LKKLELELAD ASWLKEVLDP
DTPVCFLNTE K
//
