ID A0A091Q674_LEPDC Unreviewed; 231 AA.
AC A0A091Q674;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Kinetochore protein SPC25 {ECO:0000256|ARBA:ARBA00013692, ECO:0000256|RuleBase:RU367150};
GN ORFNames=N330_11796 {ECO:0000313|EMBL:KFQ15018.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ15018.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ15018.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ15018.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367150}.
CC Chromosome, centromere, kinetochore {ECO:0000256|RuleBase:RU367150}.
CC -!- SIMILARITY: Belongs to the SPC25 family.
CC {ECO:0000256|ARBA:ARBA00006379, ECO:0000256|RuleBase:RU367150}.
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DR EMBL; KK687075; KFQ15018.1; -; Genomic_DNA.
DR RefSeq; XP_009955462.1; XM_009957160.1.
DR AlphaFoldDB; A0A091Q674; -.
DR GeneID; 104351136; -.
DR KEGG; ldi:104351136; -.
DR CTD; 57405; -.
DR OrthoDB; 103201at2759; -.
DR PhylomeDB; A0A091Q674; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR Gene3D; 3.30.457.50; Chromosome segregation protein Spc25; 1.
DR InterPro; IPR045143; Spc25.
DR InterPro; IPR013255; Spc25_C.
DR PANTHER; PTHR14281:SF0; KINETOCHORE PROTEIN SPC25; 1.
DR PANTHER; PTHR14281; KINETOCHORE PROTEIN SPC25-RELATED; 1.
DR Pfam; PF08234; Spindle_Spc25; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU367150};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU367150};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU367150};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367150};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|RuleBase:RU367150};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU367150};
KW Nucleus {ECO:0000256|RuleBase:RU367150};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001}.
FT DOMAIN 158..225
FT /note="Chromosome segregation protein Spc25 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08234"
FT COILED 68..130
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 231 AA; 27338 MW; 7AFBC28D9AB4F8D8 CRC64;
MANIKAEDEI IVFEREIKEF WTKLKSIYGT EQITQTLALR DSCKESIKVL SEKWSKKLKE
GDLMIDRIQE YNNEILQQSQ RISENQEHLT EIKSNLNQEE EQKKDLTDSI QELKEELIKK
KEIISSKTKA DKERMERLCK SKELFEERLG LEIRRIPNEQ LQFIFRHIDH KDPDKPYVFT
LSINEQGDYE VTSCIPPLDC IAEFQLKVRE TNNFSAFVAN IRKAFTALSY K
//
