ID A0A091QEK0_MERNU Unreviewed; 3371 AA.
AC A0A091QEK0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Putative E3 ubiquitin-protein ligase HERC1 {ECO:0000313|EMBL:KFQ25529.1};
DE Flags: Fragment;
GN ORFNames=N331_04174 {ECO:0000313|EMBL:KFQ25529.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ25529.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ25529.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ25529.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK697941; KFQ25529.1; -; Genomic_DNA.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 4.
DR Pfam; PF13540; RCC1_2; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 7.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000052967};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 517..708
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 1939..1980
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2137..2168
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2261..2302
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2515..2563
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2564..2618
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2619..2670
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2671..2722
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2724..2775
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2776..2827
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2828..2871
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 3011..3358
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 17..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1312..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..951
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 3321
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ25529.1"
FT NON_TER 3371
FT /evidence="ECO:0000313|EMBL:KFQ25529.1"
SQ SEQUENCE 3371 AA; 369459 MW; 7BFA26B989DCA9E8 CRC64;
SRSESLTAES RSIHASSNYR LMKSRSESDL SQPESDEEGY SLSGRRNVDL DLASSHKKRG
AIHSQVEPLS DSWARLKHSR DWLYTSSYSF VESDFDLSRS LGVHTLIENV VSFVSGDVGN
SPGFKEPEES MSTSPQAAII AMEQQQLRAE LRLEALHQIL VLLSGMEEKG SVSLMGSRQV
PGFQSSSLLT SVRLQFLAGC FGLGTVGHAG AKGESVRLHH YQDGVRAAKR SIQIEIQVAV
HKIYQQLSAT LERALQANKH HIEAQQRLLL VTVFALSVHY QPVDVSLAIS TGLLNVLSQL
CGTDAMLGQP LQLLPKTGVS QLSTALKVAS TRLLQILAIT TGTYADKLSP KVVQSLLDLL
CSQLKNLLSQ AGVMLMASFG EGEVEKDEVE SKKADSNGDS EKRDFRAALR KQHAAELHLG
DFLVFLRRVV SSKAIQSKMA SPKWTEVLLN IASQKCCSGV PLVGNLRTRL LALHVLEAVL
PACESGVEDD QMAQVVERLF SLLSDCMWET PIAQAKHAIQ IKEKEQEMKL QKQGESEDED
ENLPIQEVSF DPEKSQCCIV ENGQILTHGS GGKGYGLAST GVTSGCYQWK FYIVKENRGN
EGTCVGVSRW PVHDFNHRTT SDMWLYRAYS GNLYHNGEQT LTLSSFTQGD FITCVLDMEA
RTISFGKNGE EPKLAFEDVD AAELYPCVMF YSSNPGEKVK ICDMQMRGTP RDLLPGDPIC
SPVAAVLAEA TIQLIRILHR TDRWTHCINK KMMERLNKIK TCLKETGQKL KKSRSIQSRE
ENEVREEKEN KEEEKSKHSR HGLADLSELQ LKMLCVEVWP VLAVIGGVDA GLRVGGRCVH
KQTGRHATLL GVVKEGSTSA KVQWDEAEIT ISFPTFWSPS DTPLYNLEPC EPLPFDVARF
RGLTATVLLD LTYLTGIHED MGKQSTKRHE KKHRHESEDK GEVDQKTEGD VGSDMRLGQS
ADDNKGHSAT SSKSENEIAS FSLEPSTLGV ESQHQPGEGR KKNHEHTPRN HEIAQSEIRA
VQLSYLYLGA MKSLSVLLSC SKYAELLLIP KVLAENGHNS DCASSPVVHE DVEMRAALQF
LMRHMVKRAV MRSPIKRALG LADLERAQAM IYKLVVHGLL EDQFGGRLKQ EVDQQVEEGD
QSQQAQTPVT TSPSASSTTS FMSSSLEDTT TATTPVTDTE TVPASESPGV MPLSLLRQMF
SSYPTTTVLP ARRAQTPPIS SLPTSPSDEV GRRQSLTSPD SQPARPANRT ALSDPSSRLS
TSPPPPAIAV PLLEMGFSLR QIAKAMEATG ARGEADAQNI TVLAMWMIEH PGNEDDEEPQ
SEGTADSRHG TVVSGSGGKS GDHCYLQSPG DIPSADATEM EEGFSESPDN MDHVDNTASA
SGPPSRSRSA VTRRHKFDLA ARTLLARAAG LYRSVQAHRN QSRREGISLQ QDPGALYDFN
LDEELEIDLD DEAMEAMFGQ DLASDNDILG MWIPEVLDWP TWHVCESEDR EEVVVCELCE
SSVVSFNQHM KRNHPGCGRS ANRQGYRSNG SYVDGWFGGE CGSGNPYYLL CGICREKYLA
LKSKSKTPTS ERYKGQAPDL IGKQDSVYEE DWDMLDVDED EKLTGEEEFE LLAGPLGLND
RRIVPEPVQF PDSDPLGASV AMVTATNSME ETLMQIGCHG SIEKSSSGRI TLGEQAAALV
NPHDRVMALR RVTAAAQVLL ARTMVMRALS LLSVSGSSCS LAAGLESLGL TDIRTLVRLM
CLAAAGRAGL STSPSTVSSS AERSRGIHSK TSKPISCLAY LSTAVGCLAS NTPSAAKLLV
QLCTQNLISA ATGVNLTTVD DPIQRKFLPS FLRGIAEENK LVTSPNFVVT QALVALLADK
GAKLRPNYDK AEIEKKGPLE LANALAACCL SSRLSSQHRQ WAAQQLVRTL AAHDRDNQTT
PQTLADMGGD LRKCSFIKLE AHQNRVMTCV WCSKKGLLAT SGNDGTIRVW NVTKKQYSLQ
QTCVLNKLEG DSEESLGSPS DLSLSLVCWS ISGKYLAGAM EKMVNIWQVN GGKGLLDLQP
HWVSALTWPE EGPAAAWTGD APELLLIGRM DGSLGLIEVV DISTMHRLEL EHCCRKDVSV
TSLAWFSEDR PFAVGYSDGK LLIGTKEPLE KGGIVLVDAH KDMIVSMKWD PNGKILLTCA
REETVKLWGY MGGSWRRLHS LSHPALVNGV AWCALPGKGQ KLQLLLATGC HNGLVCVWTV
PQDIVVTLQS SSTCSERWWD QETSAKDGYR KAVEVKCVFQ LRGHITPVRT VAFSPDGLAL
VSGGLGGLMN IWSLRDGSVL QSVVIGSGAI QTAVWIPDVG VAACSNRSKD VLVVNCTSEW
ISSNHVLATC RTALKQQGVL GLNMAHCMRA FLERLPIMLQ EQYAYEKPHV VCGDQLVHSP
YMQCLASLAV GLHLDQLLCN PPVPPHHQNC LPDPSAWNPT EWAWLECFST TIKAAEALAK
GAQFPESFSV PDLEPVPEDE LTLLMDNSKW INGMDEQIMS WATSRPEDWH LGGKCDVYLW
GAGRHGQLAE AGRNVVIPVA APSFSQAQQV VCGQNCTFVI QANGTVLACG EGSYGRLGQG
NSDDLHVLTV ISALQGFVVT QLVTSCGSDG HSMALTESGE VFSWGDGDYG KLGHGNSDRQ
RRPRQIEALQ GEEVVQMSCG FKHSAVVTAD GKLFTFGNGD YGRLGLGNTS NKKLPERVTA
LEGYQIGQVA CGLNHTVAVS TDGSMVWAFG DGDYGKLGLG NSTAKSSPQK VDILCGIGIK
KVACGTQFSV ALTKDGHVYT FGQDRLIGLP EGRARNHNRP QQVPVLSGVF IEDIAVGAEH
TLALSSTGDV YAWGSNSEGQ LGLGHTNHVR EPTLVTVLQA GRCHSAAWTA PPVPPRAPGV
SVPLQLGLPD AIPPQYGALK EVSVHTVRAR LRLLYHFSDL MYSSWRLLNL SPNNQNSTSH
YNAGTWGIVQ GQLRPLLAPR VYTLPMVRSI GKTMVQGKNY GPQITVKRIS TRGRKCKPIF
VQIARQVVKL NASDLRLPSR AWKVKLVGEG ADDAGGVFDD TITEMCQELE TGIVDLLIPS
PNATAEVGYN RDRFLFNPSA CLDEHLMQFK FLGILMGVAI RTKKPLDLHL APMVWKQLCC
IPLILEDLEE VDLLYVQTLN SILHIEDSGI TEENFHEMIP LDSFVGQSAD GKMVPIIPGG
NSIPLTFSNR KEYVERAIEY RLHEMDRQVA AVREGMSWIV PVPLLSLLTA KQLEQMVCGM
PEISVEVLKK VVRYREVDEQ HQLIQWFWHT LEEFSNEERV LFMRFVSGRS RLPANTADIS
QRFQIMKVDR PYDSLPTSQT CFFQLRLPPY SSQLIMAERL RYAINNCRSI DMDNYMLSRN
VDNAEGSDTD Y
//
