ID   A0A091QKL3_MERNU        Unreviewed;       589 AA.
AC   A0A091QKL3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Alpha-L-iduronidase {ECO:0000313|EMBL:KFQ27156.1};
DE   Flags: Fragment;
GN   ORFNames=N331_05902 {ECO:0000313|EMBL:KFQ27156.1};
OS   Merops nubicus (Northern carmine bee-eater).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX   NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ27156.1, ECO:0000313|Proteomes:UP000052967};
RN   [1] {ECO:0000313|EMBL:KFQ27156.1, ECO:0000313|Proteomes:UP000052967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ27156.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 39 family.
CC       {ECO:0000256|ARBA:ARBA00008875}.
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DR   EMBL; KK700779; KFQ27156.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091QKL3; -.
DR   Proteomes; UP000052967; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR049165; GH39_as.
DR   InterPro; IPR049167; GH39_C.
DR   InterPro; IPR049166; GH39_cat.
DR   InterPro; IPR000514; Glyco_hydro_39.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR12631; ALPHA-L-IDURONIDASE; 1.
DR   PANTHER; PTHR12631:SF8; ALPHA-L-IDURONIDASE; 1.
DR   Pfam; PF01229; Glyco_hydro_39; 1.
DR   Pfam; PF21200; Glyco_hydro_39_C; 1.
DR   PRINTS; PR00745; GLHYDRLASE39.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR   PROSITE; PS01027; GLYCOSYL_HYDROL_F39; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052967}.
FT   DOMAIN          2..470
FT                   /note="Glycosyl hydrolases family 39 N-terminal catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01229"
FT   DOMAIN          499..586
FT                   /note="Alpha-L-iduronidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21200"
FT   ACT_SITE        128
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600514-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ27156.1"
FT   NON_TER         589
FT                   /evidence="ECO:0000313|EMBL:KFQ27156.1"
SQ   SEQUENCE   589 AA;  66598 MW;  C631BE97544228A4 CRC64;
     PPLPHSRADL FDLSKDQEVN LAYISSVPHG GIEQVRIHWL LELVALRVMN GKLHYDFTAL
     DNLMDRLWEN KLIPGFELMG NPSGYFFDFE DKEQVVRWRN LVTLLASRYI GRYGLEHVAK
     WNFETWNEPD HHDFDNVSMT VKGFLNYYDA CSEGLKAASP LLKFGGPGDS FHPLPKSPIC
     WSLLCHCSNG TNFFTGETGV RLDYISLHKK GGGSSLYILQ QEVEAVEQIH KLFPNFASVA
     IYNDEGDPMV GWSTPQLWRA DVTYAAMVVK VIIQHQNLLI SKASNTINYT LLSNDNAFLS
     YYPHYFTQRT LTARFQMNNT KPPHVQMVRK PVLTVMGLLA LLGENQIFAE VNSNEGESTP
     NSTIGVLASV HTPSEMQPSD SWQATLLMYS SEDNRTSSNI STVTVNATHF PKLRELVYVT
     YYLDNNQTNP YLKWRMLGSP DFPSPEQFQQ IRDAEDPVAT GPFPLPEGGI LTLKQDFPVP
     SVFLIHICAR PRSVPDQVTG VRLIPLTKGQ VIVLWDDGCI NSKCIKTFEV EFSPDGKAYQ
     RINPKDTIFT LWVYSPGRSV SGFYRVRAID YWGKAGLSSL PVEYVEAFK
//