ID A0A091R5K8_9GRUI Unreviewed; 497 AA.
AC A0A091R5K8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 23.
DE SubName: Full=Polycystic kidney disease 2-like 2 protein {ECO:0000313|EMBL:KFQ35103.1};
DE Flags: Fragment;
GN ORFNames=N332_07841 {ECO:0000313|EMBL:KFQ35103.1};
OS Mesitornis unicolor (brown roatelo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; Mesitornis.
OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ35103.1, ECO:0000313|Proteomes:UP000053369};
RN [1] {ECO:0000313|EMBL:KFQ35103.1, ECO:0000313|Proteomes:UP000053369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ35103.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
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DR EMBL; KK810363; KFQ35103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091R5K8; -.
DR Proteomes; UP000053369; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF47; POLYCYSTIC KIDNEY DISEASE 2-LIKE 2 PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053369};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..252
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 253..477
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT DISULFID 121..134
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ35103.1"
FT NON_TER 497
FT /evidence="ECO:0000313|EMBL:KFQ35103.1"
SQ SEQUENCE 497 AA; 58206 MW; 26427BF5C8A46719 CRC64;
REVELNTTLR ELLIYVAFLV DLCILTFGMV STDMYYLNEA MSHLFLEPPF SEDDRSGFGS
IRSRADFWRF AEGPLLNGLY WDKWYNNRTL TFQNSSSHIY YENLLLGVAQ IRQLRVRNNT
CSVYPSFRTF LQDCYSEYHY RAEDRSDFGL QNESEWKYTS TSSLSPWYRG SMGSYNSGGY
LFTLPKSKQE SMKKLVFLRQ NSWLTRGTRV VFVDFSTYNA NINLFCIIRL VVEFPATGGA
HTSSHIYSAK LLRYVTGYDY FLASCEVAFC CIITIFIIQE AVKIIKLKKE YFRSVWILLD
LLLLVVSIIA IVFNIYRTSK VSELMKELLS DADVYPDFYF LASWQVLYDN MIAVTIFLAW
IKIFKYVRLN NTMTQLSSTL SRCAKEIIGF GIMFFLIFFA YVQFGYLVFG SQVKDFSTFQ
NCIYTQFRIV LGDFDFEAIE EANRILGPIY FITFVFFVFF ILLNMFLAII NDTYSEVKAE
FKVKLSRELH TGDLFRR
//
