ID A0A091REX5_9GRUI Unreviewed; 816 AA.
AC A0A091REX5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 6 {ECO:0000313|EMBL:KFQ37807.1};
DE Flags: Fragment;
GN ORFNames=N332_03066 {ECO:0000313|EMBL:KFQ37807.1};
OS Mesitornis unicolor (brown roatelo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; Mesitornis.
OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ37807.1, ECO:0000313|Proteomes:UP000053369};
RN [1] {ECO:0000313|EMBL:KFQ37807.1, ECO:0000313|Proteomes:UP000053369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ37807.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; KK814738; KFQ37807.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091REX5; -.
DR Proteomes; UP000053369; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 4.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010909; PLAC.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF8; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000053369};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 362..502
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT DOMAIN 778..816
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT ACT_SITE 72
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 113
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 287
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ37807.1"
FT NON_TER 816
FT /evidence="ECO:0000313|EMBL:KFQ37807.1"
SQ SEQUENCE 816 AA; 90040 MW; 8C6D3F8677075071 CRC64;
QVEWLEQQEV KRRVKRQVRA EPQVLPFNDP VWPNMWYLHC GDKSSRCRSE MNVLAAWQRG
YTGKNVVVTI LDDGIERNHP DLLQNYDPLA SYDVNGNDHD PTPRYDANNE NKHGTRCAGE
VAATANNSYC IVGIAYNARI GGIRMLDGDV TDVVEAKSLG IRPDYIDIYS ASWGPDDDGK
TVDGPGLLAK QAFEHGIKKG RRGLGSIFVW ASGNGGRGGD YCSCDGYTNS IYTISISSTT
ENGYKPWYLE ECASTLATTY SSGAFYERKI VTTDLRHRCT DGHTGTSASA PMVAGIIALA
LEANPLLTWR DVQHLLVKTS RPVHLRAADW KTNGAGHKVS HLYGFGLVDA DAIVVEAKKW
KTVPPQHICV GSLDRVPKYI RVNHVLRTST LSGACAEHRN QHVLYLEHVV VRLSISHPRR
GDLQISLVSP AGTRSQLLAR RAFDRSNEGF KGWEFMTVHC WGERAAGEWT LEIHDTPSQV
RNPTVQGKLK EWSLIFYGTA EHPYTTPPNR GRMLEVSASE MEPSRAAFLQ SQVEVAEEEE
EYAGPCHPEC GDQGCDGPNA DQCLNCIHYS LGSVKTGRMC VSSCPVGFFG DEGARRCRRC
YKGCERCVGR GPAQCTACKR SLYHHQEMGT CVVLCPPGFY AEERQKRCLK CHQSCKKCIG
EADRCTACKD GFSLAGESCV PECQPAMYLS REPRHCEACP ATTGLGEEDC TPCTPEAPAP
HWHCVPACRE GFYPADSHGL PNKVCKRCDD HCSACEGSSG NCLRCKEGFS LLGGSCVTNE
TCTNADKTFC EMVKSNKLCE KKLFVQFCCQ TCLMAG
//
