ID A0A091S7S0_NESNO Unreviewed; 246 AA.
AC A0A091S7S0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
GN ORFNames=N333_13549 {ECO:0000313|EMBL:KFQ53702.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ53702.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ53702.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ53702.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; KK945081; KFQ53702.1; -; Genomic_DNA.
DR RefSeq; XP_010017325.1; XM_010019023.1.
DR AlphaFoldDB; A0A091S7S0; -.
DR GeneID; 104409217; -.
DR KEGG; nnt:104409217; -.
DR CTD; 627; -.
DR OrthoDB; 5399313at2759; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Signal {ECO:0000256|RuleBase:RU364086}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU364086"
FT CHAIN 19..246
FT /note="Brain-derived neurotrophic factor"
FT /evidence="ECO:0000256|RuleBase:RU364086"
FT /id="PRO_5010897772"
FT DOMAIN 132..239
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 140..207
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 185..236
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 195..238
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
SQ SEQUENCE 246 AA; 27733 MW; 0F9375DB6C15573F CRC64;
MTILFLTMVI SYFSCMKAAP MKEASVRGQG SLAYPGLRTH GTLESLNGPN AGSRGLTSLA
DTFEHVIEEL LDEEQDIQPS EENKDADLYT SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN
MSMRVRRHSD PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF
YETKCNPKGY TKEGCRGIDK RHWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL
TIKRGR
//
