ID A0A091S8A6_NESNO Unreviewed; 1293 AA.
AC A0A091S8A6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 45.
DE SubName: Full=Son of sevenless 2 {ECO:0000313|EMBL:KFQ52572.1};
DE Flags: Fragment;
GN ORFNames=N333_03279 {ECO:0000313|EMBL:KFQ52572.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ52572.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ52572.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ52572.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK943548; KFQ52572.1; -; Genomic_DNA.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840}.
FT DOMAIN 170..361
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 414..517
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 557..701
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 739..978
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 978..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1150
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1186
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1262
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ52572.1"
FT NON_TER 1293
FT /evidence="ECO:0000313|EMBL:KFQ52572.1"
SQ SEQUENCE 1293 AA; 148635 MW; B1265ABD08775352 CRC64;
QVQQQVHPNL SAKEDSLYYI EELILQLLNK LCIAQPRTVQ DVEERVQKTF PHPIDKWAIA
DAQSAIEKRK RRNPLLLPVD KIHPLLKEVL GYKVDYHVSL YIVAVLEYIS ADILKLAGNY
VFNIRHFEIS QQDIKVSMCA DKVLMDMFDQ DDIGLVSLCE DEPSSSGELN YYDLVRNEIA
EERQYLRELN LIIKVFREAF LSNRKLFTPN DIDVIFSNIS DIHELTVKLL GLIEDTVEMT
DESSPHPLAG SCFEDLAEEQ AFDPYETLSQ DILSPQFHEH FNNLMAKPAV ALHFQSTAEG
FKEAVRYVLP RLMLIPVYHC LHYFELLQVN EATLFEDEED RECLKQAITA LLNLQCSMER
IYSKHSPRRR PGEPVCRFYH RQIRSKHLAI KKMNEIQKNI DGWEGKDIGQ CCNEFIMEGS
LTKIGAKHER HIFLFDGLMI SCKTNHGQSR LPGYSNAEYR LKEKIVMRKI QIIDKDDTSE
YKHAFELVSK DENSILFAAK SAEEKSNWMA ALISLQYRST LDRMLDSVLL QEENEQPLRL
PSPNVYRFVV EDSEVNGIPI IKGGTVVKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL
LSLLIERFEI PEPEPTEADR LAIEKGEQPI SADLKRFRKE YVQPVQLRIL NVFRHWVEHH
FYDFERDLEL LERLETFISS VRGKSMKKWV ESIAKIIKRK KAQANGISHN ITFESPPPPV
EWHIWRVGHS ETLDLMTLHP IEIARQLTLL ESDLYRAVQP SELVGSVWTK EDKEINSPNL
LKMIRHTTNL TLWFEKCIVE TENFEERVAV LSRIIEILQV FQDLNNFNGV LEIVSAMNSV
SVYRLDHTFE ALQERKKRVL DEAVELSQDH FKKYLAKLKS INPPCVPFFG IYLTNILKTE
EGNPDFLKRQ GKELINFSKR RKVAEITGEI QQYQNQPYCL RIEPEIRKFF ENLNPMGKIP
EKEFTDYLFN KSLEIEPRNC KQPPRFPRKT TYPLKSPGIR PNTGRHSSTS GTLRSHPLPL
EKEPSKISFS RITEAEHEST VSAPTSPNTP STPPVSASSE FSVFLDIDLN SSYGNNSIFA
PVSLPQSKTF FSSWGSFPKL SDEPQNPPPL PPRKKLDQDA SNAKGSLKSD DDPPAIPPRQ
PPPPKIQPRA PAYTNPFDQP LHSPPPPPPR DPLPDTPPPV PLRPPEHFVN CPLNLQLPPV
GRLHRDPDWF REASTGPSSP STPPSTPSPR VLRRCCVIST SHNNVVHPPV PPVPPRHNSS
PQLPKLPPKT YKRELSHPPL HRLSLLENAE TPQ
//
