UniProt: A0A091T6P6

Database: UniProt
Entry: A0A091T6P6_PHALP

LinkDB:  A0A091T6P6_PHALP 
Original site:  A0A091T6P6_PHALP

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Ontology (2)   
   GO (2)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (11)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
   SMART (3)   
All databases (14)   

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ID   A0A091T6P6_PHALP        Unreviewed;      5837 AA.
AC   A0A091T6P6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Nesprin-1 {ECO:0000313|EMBL:KFQ69247.1};
DE   Flags: Fragment;
GN   ORFNames=N335_14133 {ECO:0000313|EMBL:KFQ69247.1};
OS   Phaethon lepturus (White-tailed tropicbird).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC   Phaethontidae; Phaethon.
OX   NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ69247.1, ECO:0000313|Proteomes:UP000053638};
RN   [1] {ECO:0000313|EMBL:KFQ69247.1, ECO:0000313|Proteomes:UP000053638}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ69247.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the nesprin family.
CC       {ECO:0000256|ARBA:ARBA00008619}.
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DR   EMBL; KK437757; KFQ69247.1; -; Genomic_DNA.
DR   PhylomeDB; A0A091T6P6; -.
DR   Proteomes; UP000053638; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR   CDD; cd00176; SPEC; 10.
DR   Gene3D; 1.20.58.60; -; 25.
DR   InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR   InterPro; IPR012315; KASH.
DR   InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR   PANTHER; PTHR21524:SF7; SPECTRIN REPEAT CONTAINING, NUCLEAR ENVELOPE 1; 1.
DR   Pfam; PF10541; KASH; 1.
DR   Pfam; PF00435; Spectrin; 12.
DR   SMART; SM01115; cwf21; 1.
DR   SMART; SM01249; KASH; 1.
DR   SMART; SM00150; SPEC; 32.
DR   SUPFAM; SSF46966; Spectrin repeat; 31.
DR   PROSITE; PS51049; KASH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00385};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM        1..5786
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT   TRANSMEM        5787..5807
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TOPO_DOM        5808..5837
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT   DOMAIN          5778..5837
FT                   /note="KASH"
FT                   /evidence="ECO:0000259|PROSITE:PS51049"
FT   REGION          2886..2913
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5286..5320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5716..5772
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          234..261
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          430..457
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1171..1198
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1514..1567
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1788..1825
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2093..2120
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2177..2204
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2436..2495
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2654..2681
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2760..2835
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3092..3119
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3259..3289
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4090..4117
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4196..4226
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4326..4379
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          4852..4879
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2889..2913
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5288..5310
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5716..5766
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ69247.1"
FT   NON_TER         5837
FT                   /evidence="ECO:0000313|EMBL:KFQ69247.1"
SQ   SEQUENCE   5837 AA;  671455 MW;  19708FE225CBB367 CRC64;
     LAAWTQGLAP LDNRCTDAEV AESWRKEKET LDALLKSEHM TDEIKTQLND LCRFSRDLST
     HSSKVSGLIK EYNSLCLQAS KGCQSKEQIL QQRFRTAFRD FQQWLVNAKV TTAKCFDVPQ
     NIGEASASLQ KIQEFLSESE NGQQKLNLVA SKGELLCSVL PKEKAKVIRD KSATAKEDWK
     KFITTLHQKE SALENLKIQM KDFEATAEPL QEWLTTTEKI VQGSSSRLHD LPSKRREQQK
     LQSVLEEISC HEHQLNGLKE KAQQLWEEQA VSKSFMRRVS QLSSQYLTLS NLTKEKVSRM
     DRVVAEHQQF SHSVKDLQDW VADAVHMLDS YCHPTADKSV LDSRMLKLEG LLAVKQEKEI
     QMKMVLTRGE SVLQNTSLEG VPVIERQLQT LKDSWASLLS ACIQCKSQLE GALSKWTSYQ
     DDVRQFSSWM DKVEASMNAS ERQYAELREK TAALSKAKLL SEEVLSHSSL LETIEVKGSG
     MAEHYVTQLE LQDLQERYKF LQDRTREAVT KAEGLLNLHQ DYQRNLKAFE VWLEKEQEKL
     DCLSHLDGDA QKQEATLRDL QELQVRCAEG QALLNAAVHS REEVIPWGFP QIEDRALESL
     RQDWQVYQHR LSEARSQLNA TVSRLRLMEK KFQKVNEWLI DLEEKVAIRT GRQSGRATKE
     MQLQQMKKWH EEITIYKDDV EEVGVLAQQI LEESLTASRM GSQATQLTSR YQTLLLHVLE
     QIKFLEEEIR CMEESELAFS AYTNWYGATI KNFRNVITKF EVVDKTAMEK KVQKLELLLS
     DMDIGYSLLK SAREKGERAI KYMGENEVDQ IRKEIGDHVE QLEELAGSIR KELMTSEKCL
     QLAKEFSDKY KAQTQWVMEY QAMLHAPAEP KSELYEKKAQ LSKYKSIQQT VLSHEPSIKS
     VIEKGEALFD LVNDVALKNN IQDLQSSYQE LCSTTKAYVE TLEVRVKEHE DYNSDLQEGE
     KWLLHMSSRL VSPDLMESNS LEIITQQLAN HKAIMEEIAG FEDRLNNLKS KGDYLINQCT
     EHLQAKFKQN IQSHLQGTKD SYSAICSTAQ RVYQSLEHEL QKHVNHQDTL QQCQTWLSTV
     QSELKPTTWT PFSLADAVKQ VKHFRALQEQ ANTYLDLLCS MCDLSDATVK STATNIQQTK
     QMIEQQIMHS QYLAQGWEEI KQMKAELWMY FQDADQQLQN LKRRRAELEL NIAQNMVLQV
     KEFSQKLQSK QSALTSVTEK MNKLTQGQES PEHKEIGELS NQWLDLCLQA HSLLIQREED
     LQRTGHYHER MNVVEVFLEK LTKEWDNLAR SDAESTHVHL EALQKLAVAL QERRFALEDL
     KDQKQKMIEH LNLDDKELVK EQCGHFEQRW TQLEDLVKRK IQVSVSTLEE LSLVHSKFRE
     LMEWAEEQQP SVSEALKQSP PPDLAQSLLM DHLTICSELE AKQLVLKTLV KDADRVMTNL
     GLNERQELQK VLSDAQHHVD CLSDLVGQRR KHLNKALSEK TQFLMAIFQA TNQIHQHEKK
     VTFPEHICLL PEDVNKQIRI CKNAQANLKA YQTEVTGLWA QGRDLMKEAT EQEKSEVLGK
     LQELQNVYDT VLQKCNQRLL ELEKNIVSRK YFKEDLDKAC HWLKQADIVT FPEVNVMNSN
     SELYSQLAKY QQILEQSPEY ENLLLALQRD GQEILPSLNE VDHSYLNEKL NIIPQQFNIV
     TALAKEKLYK VQEAIYARKE YASLIELTSK ALTELEDHFI NMDKAPAAVL AKEAVSLQQA
     YTDLLGEVVS LGAAVDELNQ KKEAFRSTGQ PWQPDEMLKL VRLYHKLKRQ IEQKISLLED
     TVEACQEHEK MCMQFEAQLE AVRKQQIKVN EETLPIEEKL KIYHSLVGSL QDSGSLLKRI
     TEHLEALSPQ LDSSACEATN HQVQSWQEKL KSLHAAIGDT VMECENRLVQ SIDFQTEICR
     SLNWLRQVKT ELNGTLSLDL KLQSIQEEIR KVQIHQEEVQ SSLRIMNALS NKEKERSMKA
     KELIPADLEN TLAELTELDG EVQEAIHMRQ ATLNKLYSFC QRYYEVMQIA NDWLEDAQEF
     LHLARNGLDV ENSEENLRNH MEFFSTESQF SNHLEELQGF VSEIEPFIQA TAREQLVQNV
     VELEEKAKGT KQDAKTQKEQ LQRCVSEWQE YQTERQKVIE VMNEAEKKLS EFSVAKAASS
     HEAEEKLITH KTLVSVVNSF HEKITALEEK VSQLEKVSND ASKATISRSM TTVWQRWTRL
     RNVAQEQEKV LEDAVQEWKG FNDKIQKATI AIDQLQGRLP ESSVEKASKT DLLELLDYHS
     SFLLEVEHQL SSLGLLKQHA VSMLQDVEIK PPSQEELPVM QEIKAMQDRC HNMQQKVKKG
     VKVVKQELKE REEVEAEINI VKSWIQETKE YLLSPDVEVD TQLQELQSLL GEVTTHRQAV
     EKMAEQQQNK YLGLYTILPS ELSLHLAEVG LALVTVQDQI QNKERETQQI KTLNQEFGQK
     IQGIANELNA ILSKLKKKTN DIAQAKLEQK ILSEELDSCN IKLLELDASV QDFAEQNVPL
     AKQLANRIGK LTALHQQTIR QAEYRAAKLS QAASHLEEYN EVLEFILKWI EKANILVHGS
     IIWNSSSQLR DQFKAYQTML DESGEIHGDL EAMSERIEYL ASVYYTEEMS QQVLELGRRT
     EELQQVIKVR LPNLQDAAKD MKKFEFELRA LQAALEQAQA TLTSPELGHL SLKEQLSHRQ
     HLLSEMESLK PKVHAVQVSQ SALRIPEEVV TGLPMCHRAL RLQEEASRLQ HTAIQQCNIM
     QATVVQYEQY EQEMKHLQQM IENAHREIQD KPIATSNIQE LQVQISHHEE LAQKIKGYQE
     QIASLNSKCK MLTMKAKHAT MLLTVTEVEG LAEGMEELDS DLLPAHPAHP SVVMMTAGRC
     HTLLSPVTEE SGEEGTNSEI SSPPACRSPS PVANTDASVN QDIAYYQALS AEQLALSAEQ
     LQTEAAKIQP STSATQEFYE PGLESAASAK LDDLQRSWET LKNVISEKQR TLYEALERQQ
     KYQDTLQSIS TKMETTEIKL NESLEPAKSP ETQMAEHQAL MDEILMLQEE ITELQTSLAQ
     ELVSEPLDAE AADQLALQST LTVLAERMAT IRMKASGKRQ LLEEKLNEQL EEQRQEQALQ
     RYRCEADELD HWLLNTRATL DNTVVSAEEP MDMEAQLVDC QNMLVEIEQK VVALSELSVH
     NENLLMEGKA HTKDEAEQLA VKLRTLKGSL LELQRVLHDK QINIQQASLQ EKEESDLDFV
     SSQSPSVQEW LAQARTTRSQ QQQSTLQQQK ELEQELEEQK SLLRSVACRG EEILTQKGAP
     EGLCISEKPD TLSEELGLEG EKPSSEEQMK MKWENLNQEF NTKQKLLQKA LEQEQLQLYS
     RPNRLLSGMP LYKEEGQRED KSSVSPVLIE LNQAFENVSS EAGQVVESLH LEQKLYDGVT
     ATSLWLDGVE EQVFVAAALL PEEETEAYLC KQEFLAKEIK EITEEMDKNK NLFAQIFPES
     GVNRDIIEDT LDCFLRRLTL LESIVNQRCH QMKGRLQQIV TFKNDLKLLF TSVADNKYLV
     LQKLAEAAER PETEQMQVIL QAEEGLKELD TGINELKKHV DKLQIDQPSV QDLSKIQDMY
     DELMMIIGSR RSDLNQNLAL KRQYERALQD LADLLETGQE KMAGDQKMIV ASKEEVRSLL
     DKHKEYFQGL ESHMILTETL FRKMSSFALL KETQSHSELM IQASAVLKLA HKRGVELEYI
     LETWMRLDED YQELTRQLES VEGSIPTVGL VEETEDRLTD RITLFQHLRS SLTEYQPKLY
     QVLDDGKRLL FSVSCSDLES QLNQLGEHWL SNTSKVTKEL HRLETILKHW TRYQSESSEL
     THWLQSAKER LEFWSQQSLT VPQELETVRD HLNSFLEFSK EVDAKSSQKS SVLSTGNQLL
     RLKKVDTAAL RAGLSHIDSQ WTELLTQIPA VQEKLHQLQM DKIPSRHAIT EVMSWISLME
     NVIQQDEENI KNVVGQEVIQ DYVQKYKGFK IDLNCKQLTV DFVNQSVLQI SSQDVESKRS
     DKTDFAEQLG AMNRRWQILQ GLITEKIQLL EGLQESWAEY ENNVQCLKTW FETQEKKLKQ
     QQKIGDQASV QNALKDCQEL EESIRTKEKE VENVEQSGLS LIQNKKEDVS SAVMNTLQGI
     NQSWANLDHM VSQLQILLQS VLDQWSIYKV AYEELNSYLT EARYSLSRFY LLTGSLEAVK
     VQVDNLQSLQ DELEKQEDSL QKFGSVTNQL LKECHPPVTE TLINTLKEVN MRWNNLLQEI
     AERLRASKGL LQLWQRYKDC YQQCSSTVRQ REDQTNELLK TATSKYIADD EVTTWIQDCN
     DVLTDLKTAQ ESLVVLQELG EELKSQVEAS AAAAIQSDYL SLNQNLSTLE QALRKQQAVL
     QAGVLDYQTF AKNLQVLEAW ITAAEEVLKG QDPSHSSELS AIQSRMEELK CQMLKFSSMA
     PDLDRLNELG YRLPLNDKEI KRMQNLNRHW SLISSQTTER FSKLQSFLLQ QQTFLEKCET
     WMDLLVQTEK KLAAEISGNY QSLLEQQRAH EASYHLFQAE MFSRQQILHS IISDGQHLLE
     QGQVDDRDEF NLKLTLLSNQ WQGVIRRAQQ RRGIIDSQIH QWQRYREMAE KLRKWLVEIS
     CQPVSGLGNV PIPLQQARAL LDEVQLKEKV LLRQQGSYIL TVEAGKQLLL SADSGAEAVL
     QTELTEIQEH WKIASTQLEQ QKKQLALLLK DWEASEKGIG DSLEKLRSFK KNLSQPLPEH
     HDELHAEQIR CKELENAVEG WTDDLAHLSL MKETLSVYIS ADDISILSER IELLHRQWEE
     LCHQASIVSL RRQQVSERLN EWAVFSEKNK ELCEWLTQME SKVSQNGDIL IEEMIEKLKK
     DYQEEIAVAQ KNKIQLQQMG ERLAKASHES KASEIEYKLG KINDRWQHLL DLIAARVKKL
     KETLVAVQQL DKNMSSLRSW LAHIESELSK PIVYEACDSE EIQRKLNEQQ ELQRDIEKHS
     TGVASVLNLC EVLLHDCDAC ATEAECDSIQ QATRNLDRRW RNICAMSMER RLKIEETWRL
     WQKFLDDYSR FEDWLKNSER TAAFPSSSGV LYTVAKEELK KFEAFQRQVH ESLTQLELIN
     KQYRRLAREN RTDSDCSLKQ MVHEGNQRWD NLQKRVTSIL RRLKHFIGQR EEFETARDSI
     LVWLTEMDLQ LTNIEHFSEC DVQAKIKQLK AFQQEISLNN NKIEQIIVQG EQLIEKSEPM
     DATVIEEELD ELRRYCQEVF GRVERYHKKL IRLPLTDDEH DLSDREMDLD ESTDLSDIHW
     HDKSADSVLS PHPSSNLSLP LSQPVRSERS GRDTPASVDS IPLEWDHDYD LSRDLETAVS
     RALHSEEEDG GQEKDFYLRG AAGIAGEPGA LEAHIRQLDK ALDTSRFQIQ QTENIIRSKT
     PTGPELDSSY KGYMKLLGEC SGSIESVKRL GYKLKKEEEK LSGLINLNST ETQTAGVIDR
     WELIQAQALS KELRMKQNLQ QWQQFNSDLN RVWAWLGETE EELEKLRCLD LSTDIQTIEL
     RIKKLKELQK AIDNRKAIIL SINLCSSEFT QSDSEESKKL QERLSQMNVR WDHVCSMIEE
     WRCSLQDALM QCQDFHEMSH GLLLWLENID RRKNEIVPIN PNLDSETLQD HHRLLLQIRR
     ELLESQLKVA SLQDMSCQLL VNAEGKDCLE AKEKVHVIGN RLKLLLKEVT RHIKDLEKIL
     DISSSQLELS SWSSADELDT SGSVSPVSGR STPSRQRTPR GKCSLSQPGP SVSSPHSRST
     RGGLGSSRSE AGPAWRRPSF FLRVLRAALP LQLLLLLLIG LACLVPMTEE DYSCTMANNF
     ARSFHPMLKY MNGPPPL
//

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