ID A0A091T743_NESNO Unreviewed; 406 AA.
AC A0A091T743;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein {ECO:0000256|ARBA:ARBA00040901};
GN ORFNames=N333_10406 {ECO:0000313|EMBL:KFQ53580.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ53580.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ53580.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ53580.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC pathway. {ECO:0000256|ARBA:ARBA00037579}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; KK944936; KFQ53580.1; -; Genomic_DNA.
DR RefSeq; XP_010017201.1; XM_010018899.1.
DR AlphaFoldDB; A0A091T743; -.
DR GeneID; 104409108; -.
DR KEGG; nnt:104409108; -.
DR CTD; 64224; -.
DR OrthoDB; 5406902at2759; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd17119; Ubl_HERP2; 1.
DR InterPro; IPR039751; HERPUD1/2.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12943:SF5; HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 2 PROTEIN; 1.
DR PANTHER; PTHR12943; HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..71
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 85..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 44921 MW; 5D2916D81A6A4CCF CRC64;
MDQSVVDHPV TLIIKAPNQK YTDQTINCFL DWTVGKLKSH LSKVYPSKPS TKDQRLVYSG
RLLPDHLQLK DVLRKQDEYH MVHLVCTSRT PPSSPKPTTS REGHGASASS SSSNLDRSGS
TAASAPNQEA SSTSLNTSAD GVRHRNPPQA QSNPMLSHQF PYLMQGNIGN QFPGQSVPAG
FSMYPAFSPL QMIWWQQMYA RQYYMQYQAA VSAQVTSSTE PVRSAVAQAV NSEQAPANEP
AAVPNVAVQD NRPVNPNVQM NAQGGPVVNE EDFNRDWLDW MYTFSRAAIL LSIVYFYSSF
SRFVMVMGAM LLVYLHQAGW FPFRQEGGQQ QAANNADVNR DGQHANNPDL EEMERLMDDG
IDEDSGEDAG EDANTEQQPG FMASAWSFIT TFFTSLIPEG PPQVGN
//
