ID A0A091THS8_PHALP Unreviewed; 577 AA.
AC A0A091THS8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=WSC domain-containing protein 1 {ECO:0000313|EMBL:KFQ74094.1};
GN ORFNames=N335_11991 {ECO:0000313|EMBL:KFQ74094.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ74094.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ74094.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ74094.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR EMBL; KK451965; KFQ74094.1; -; Genomic_DNA.
DR RefSeq; XP_010284498.1; XM_010286196.1.
DR AlphaFoldDB; A0A091THS8; -.
DR GeneID; 104620091; -.
DR KEGG; plet:104620091; -.
DR CTD; 23302; -.
DR OrthoDB; 3971278at2759; -.
DR PhylomeDB; A0A091THS8; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF5; WSC DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 142..234
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 245..342
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 577 AA; 66081 MW; 1B44CE3078D30B31 CRC64;
MAKAFFRLQK FLRRTQFLLF FLTAAYLMAG SLLLLQRTRL VIQQGSRGTS ANQAPPVPDG
VARVGIVDPR TLQNAHPGPR LLVGMDTLQD RALDQQHSPR WLVSRNSELR QLRRRWFHRF
ISDQEPMQTA GFKAVKHSAE HRGTYVGCFS DESRERTLKG AVFYDLRKMT VSHCQEACAE
RAYTYAGLAY GAECYCGNKL PATASKPEEC NSECKGEKGS VCGGVNRLSV YRVEELRAGA
RRRRNVIYRG CFRAPENLTD TFPASLIQPN LTVEMCSEFC SKKEFPLAVI RGRECYCGYP
TGHFSLRDSA DGLLCSGMHN ASSTAEGKYC LVYQTPVQDT RCTDRKFLTA KSKVFVALSS
FPGAGNTWAR HLIEHATGYY TGSYYFDGAL YNKGFKGEKD HWRSRRTICV KTHESGKTEI
EMFDSAILLI RNPYKSLMAE FNRKYAGHLG YATDRNWKSK EWPDFVNSYA SWWASHVLDW
LKYGKRLLVV HYEDLKQSLI PKLKEMVEFL NMTVTEDRLL CVENNRDGNF KRSGAKQKDF
EPFTQEMKDL INRYILTVDE ALRERNFTGL PREYVPR
//
