ID A0A091UBI0_PHORB Unreviewed; 1305 AA.
AC A0A091UBI0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE Flags: Fragment;
GN ORFNames=N337_08167 {ECO:0000313|EMBL:KFQ87891.1};
OS Phoenicopterus ruber ruber.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Phoenicopteriformes; Phoenicopteridae;
OC Phoenicopterus.
OX NCBI_TaxID=9218 {ECO:0000313|EMBL:KFQ87891.1, ECO:0000313|Proteomes:UP000053700};
RN [1] {ECO:0000313|EMBL:KFQ87891.1, ECO:0000313|Proteomes:UP000053700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N337 {ECO:0000313|EMBL:KFQ87891.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; KK426517; KFQ87891.1; -; Genomic_DNA.
DR Proteomes; UP000053700; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18017; DEXHc_RecQ3; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF120; WERNER SYNDROME ATP-DEPENDENT HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KFQ87891.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053700}.
FT DOMAIN 466..632
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 657..809
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1054..1133
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 982..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1261..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ87891.1"
FT NON_TER 1305
FT /evidence="ECO:0000313|EMBL:KFQ87891.1"
SQ SEQUENCE 1305 AA; 146178 MW; 3A9AFF39A4981483 CRC64;
QRSVLEDGLP FLEFRGSVVY SYEASDCSLL SEDIRQSLSD GAAVGFDIEW PPSYTKGKMA
KIAVIQICAT EEKCYLFHIS SMSGFPKGLK RLLEDETIKK VGVGIEGDQW KLMSDFEIKL
KSFVELADVA NEKLKCKEIW SLNGLVKHLF GKQLLKDKSV RCSNWEEFPL TEEQKLYAAT
DAYAGFITYQ KLKNMNNSDW KLFDLRRDDT LSEDVKERLT SLAEEITDLA SRIPVSSGQL
ENLQRASEIL ANISENVSAL RSTLLANVER QKVEMPEFAK KLEGDFNICS DATLAGFWEG
DVNEEAERGN TVEDGAVAAS STDKADRDDF MSLDITEQEL QILEREAAEE FLNEAVPEEA
CSTDNEQNVS CVIESDEELE MEMLKSLEDV DNSKGALTER ESNKARKTPD TELNVVLDGE
EDEGIEEEEE ERWDPLLPVP TERQIVCLKE YFGHSAFKPV QWKVINSVLE DRRDNLVVMA
TGYGKSLCYQ FPPVYTGYTG IVICPLISLM EDQVLQLTMS QIPACLLGSA QSKDIKECIK
AGQYRVIYMT PEFCSGNLKL LQELDQTIGI TVIAVDEAHC ISEWGHDFRN SFRSLGSLKK
ALPSVPIVAL TATASPSIRK DIVNCLNLKN PQVTCTSFDR PNLYLEVGRQ SGNIIRDLKQ
FLIRKGNSSA YEFEGPTIIY CPSRKATEQV VSELIKLNVA CSAYHAGMGI KQRRETHHRF
MRDEIQCVVA TVAFGMGINK ADIRMVIHYG APKEMESYYQ EIGRAGRDGL PASCHVLWTA
TDLAFNRRLL SEIYNEKFRL YKLKMLAKIE QYLVSNSCRR KIILSHFEDK QLRKVSSGIM
GTEECCDNCR SRASCLATSS DSEGGLQDFG KQAYQLLSAV SALEEKFGTT VPILFLRGSS
SQRLPERYRR HPLFGSGKDW PENWWKLLSQ QLIMEGFLKE VSGRGKFTTT CVFTQKGRNW
MSKAGSASNP SLLLQSSEDL NLQKPPRSSR PLPVLSTQRS PDTKGTTRSP VKQVCMSTTP
LVLCRPSLLV VPERSLVKSS PLKSPEPVVS SREKELEAAL YGKLLTARQK IANEKVIPPA
VLATNKILVE MARVRPTTVK NVKRIDGVSE AKSTMLIPLL AEIKDFCQVN GLQTDVFPTS
GSKDQTEASP WKCTRALSPS EHVTYVLFQE KNLSVSTISE SRSLPLSEVG THLFQAMKAG
YPVNLERAGL TPEVQQIISD VIRNPPIGSD TTKIQAIRKL VPANIELYLI RMTIALLEKE
DKKKSRGGSS VNRMLVWSDE QQEKKGADQA SREDALWNKT KVSKR
//
