ID A0A091UC25_PHALP Unreviewed; 1209 AA.
AC A0A091UC25;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Putative G-protein coupled receptor 125 {ECO:0000313|EMBL:KFQ71588.1};
DE Flags: Fragment;
GN ORFNames=N335_07055 {ECO:0000313|EMBL:KFQ71588.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ71588.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ71588.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ71588.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; KK445752; KFQ71588.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091UC25; -.
DR PhylomeDB; A0A091UC25; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15999; 7tmB2_GPR125; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF2; ADHESION G PROTEIN-COUPLED RECEPTOR A3; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFQ71588.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 884..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 913..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..230
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 213..308
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 644..931
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 962..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1069
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ71588.1"
FT NON_TER 1209
FT /evidence="ECO:0000313|EMBL:KFQ71588.1"
SQ SEQUENCE 1209 AA; 134730 MW; E159C3612F9A1A0D CRC64;
DLKNNLISTI GPGAFLGLSS LKRLDLTNNR IGCLNADVFR GLVNLIRLNL SGNLFSTLTQ
GTFDHLGSLK SLEFQTDYLL CDCNILWMHQ WLKERNITVR ETKCAYPKSL QSQTVTGVKQ
ELLTCEPPLE LPSFYMTPSH RQVVFEGDSL PFQCMASYID QDMQVLWYQD GKIVETDESQ
GIFVEKNMIH NCSLIASALT ISNIQAGSTG NWGCHVQTRR GNNTRTVDIV VLESSAQYCP
PERVVNNKGD FRWPRTLAGI TAYLLCTRYS AGSGIYPGNS QDERRAWRRC DRGGYWAEED
YSRCQYANDV TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE AANFSDKMDV IFVAEMIEKF
GRFAEKYKEL GDVMVDIASN IMLADERVLW MAQREAKACT RIVQCLQKIA MYRLANGAQV
YSTYSPNIAL EAYVIKAAAF TGMTCTVFQK VATSDRTGLS EYGRRDPDGN LDKQLSFKCN
VSNTLSSLAL KNTIVEASIQ LPASLFTQKQ KREIRPADES VYKLQLIAFR NGKLFPATGN
STNLADDGKR RTVVTPVILT KIDGLNLASH HVPINVTLRR IAHGADAVAA QWDFDLLNGQ
GGWKSDGCRI LLSDENITTI QCYSLSNYAV LMDLTGAELY TQPADLLHPV IYATAMVLLM
CLLMIIISYI YHHSVIRISV KSWHMLVNLS FHIFLTCVMF IGGITQTRHA SICQAVGIIL
HYSTLATVLW LGVTSRNIYK QVTKKAKRCQ DPDEPPPPPR PMLRFYLIGG GIPIIVCGIT
AAANIRNYGS RPNAPYCWMT WEPSLGAFYG PASFIIFINC MYFLSIFIQL KRHPERKYEL
KEPIEEQQRL ATNEHGELAH QDSLSVSLVS TSALENEHSF QAQLLGVGLT LLLYVALWIF
GALSVSLYYP MDLIFSCFFG ATCLSLSAFL MVHHCVNRED VRHAWITTCC PGRSTYSVQV
NVQPSSSSGT NGEAPKCTNS SAESSCTNKS VSSLKNSSQG CKLTNLQAAA AQCHPTSLPL
NTGPQLDNSL TEHSVDNDIK MHVAPLEVQF RTNGHPSRHH KNRSKGHRAS RLAVLREYAY
DVPTSVEGSV QNGLPKSRQS NSEAHSRSRR AYLAYRERQY NQSQQDSSDA CSTLPKSSRN
TEKTIATNNK KDILRKPIAV ELENQQKSYG LNLAVQNGPL KSSGQDGPLL TADSTGNIRT
GLWKHETTV
//
