ID A0A091UNE5_NIPNI Unreviewed; 330 AA.
AC A0A091UNE5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Pseudouridine synthase I TruA alpha/beta domain-containing protein {ECO:0000259|Pfam:PF01416};
DE Flags: Fragment;
GN ORFNames=Y956_05960 {ECO:0000313|EMBL:KFQ91872.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ91872.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ91872.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ91872.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; KL409758; KFQ91872.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091UNE5; -.
DR STRING; 128390.A0A091UNE5; -.
DR eggNOG; KOG2553; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02568; PseudoU_synth_PUS1_PUS2; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041708; PUS1/PUS2-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF4; PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 165..267
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT ACT_SITE 72
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-1"
FT BINDING 127
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ91872.1"
FT NON_TER 330
FT /evidence="ECO:0000313|EMBL:KFQ91872.1"
SQ SEQUENCE 330 AA; 37840 MW; 5D30431F48BDCC6B CRC64;
EDQNKKSPKR KIVLLMAYSG KGYHGMQRNV GSSQFKTIED DLVSALVQSG CIPENHGEDM
KKMSFQRCAR TDKGVSAAGQ IVSLKVRLID DILEKINNHL PSHIRILGLK RVTGGFNSKN
KCDARTYSYM LPTFAFAHKD QDVQEEVYRL DRETLERVNK LLACYKGTHN FHNFTSQKGP
RDPSAKRYIM EMYCGEPFVR ENIEFAVIKV KGQSFMMHQI RKMIGLVIAI VKGYAAESIL
ELSWGEEKVD VPKAPGLGLV LERVHFEKYN RRFGNDGLHE PLEWTEEEEK IAVFKEQYIY
PTIINTEREE KSMVNWLNTL SIHDFSSSAV
//
