ID A0A091URD6_PHALP Unreviewed; 402 AA.
AC A0A091URD6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Growth/differentiation factor 10 {ECO:0000256|ARBA:ARBA00040122};
DE AltName: Full=Bone morphogenetic protein 3B {ECO:0000256|ARBA:ARBA00042879};
DE Flags: Fragment;
GN ORFNames=N335_06680 {ECO:0000313|EMBL:KFQ79707.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ79707.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ79707.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ79707.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KK461988; KFQ79707.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091URD6; -.
DR PhylomeDB; A0A091URD6; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:InterPro.
DR CDD; cd19394; TGF_beta_GDF10; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR017197; BMP3/BMP3B.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF145; GROWTH_DIFFERENTIATION FACTOR 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037403; BMP3/GDF10; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037403-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 290..402
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 192..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 300..367
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 329..399
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 333..401
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 366
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ79707.1"
FT NON_TER 402
FT /evidence="ECO:0000313|EMBL:KFQ79707.1"
SQ SEQUENCE 402 AA; 45999 MW; D35FA6C9EA368C7B CRC64;
AQDMVAVHML KLYEKYNREG SRPGDGNTVR SFKARPEFLA QKPLYCFNLT SMQDSEMILA
ATFHFYADKR PRHREVFCKR SKNSSCRLLH LPPILRLNVI FQSIHQNSAY GLVKGNISVS
LQRRGSWHAK DISNIIKESK RAGELILCAE LDAGEKHQGF PEQVASHLPY ILVYANDLAI
SEPNSVAVTL QRYDPFPSND GDPNLSPNAS TDTRVRRDTY LSSSIQNNEL PEVDYNNNKY
NKHDIWENVY KSLKPKASRK DRRRKGQENT ETLTKSQVLN FDEKTMKKAR RKQWNEPRIC
SRRYMKVDFA DIGWNEWIIS PKSFDAYYCA GACEFPMPKI VRPSNHATIQ SIVKAVGIIP
GIPEPCCVPD KMSSLSVLFL DENKNVVLKV YPNMSVETCA CR
//
