ID A0A091UVE7_NIPNI Unreviewed; 575 AA.
AC A0A091UVE7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Peptidase M3A/M3B catalytic domain-containing protein {ECO:0000259|Pfam:PF01432};
DE Flags: Fragment;
GN ORFNames=Y956_01995 {ECO:0000313|EMBL:KFQ94387.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ94387.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ94387.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ94387.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|RuleBase:RU003435}.
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DR EMBL; KL410135; KFQ94387.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091UVE7; -.
DR MEROPS; M03.002; -.
DR eggNOG; KOG2089; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06455; M3A_TOP; 1.
DR Gene3D; 1.10.1370.40; -; 1.
DR InterPro; IPR024080; Neurolysin/TOP_N.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804:SF44; NEUROLYSIN, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT TRANSMEM 509..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 152..482
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ94387.1"
FT NON_TER 575
FT /evidence="ECO:0000313|EMBL:KFQ94387.1"
SQ SEQUENCE 575 AA; 66772 MW; E4143CF659353202 CRC64;
TVERSMLDFP QHVSPDKEVC LASTEADKKL SNFDVEMSMR EDVFQKIVYL QQTCDLENVK
PETKRYLEKS VQVGKRNGLH LPKEVQNEMK TMKKKLSELC IDFNKNLNEE NTFLVFSKEE
LEGLPDDFIK SLEKTEEDKY KITLKYPHYF PVMKKCCISE TRRKMESAFN SRCKEENTKI
LQQLLPLRAK VAELLGYNTH ANFVLEVNTA KSTDNVTAFL DDLSKKLKPL VEEEREFILD
LKKKECKERN FDYDGRINAW DLHYYMNKTE ELKYSIDQEK LKEYFPIEAF TEGLLNIYQK
LLGLVFEQVE SAHVWHDSVT LYTVKDNSTG EMLGQFYLDL YPREGKYGHA ACFGLQPGCL
LSDGSRMMSV AALVTNFTKP ASDRPSLLRH DEVKTYFHEF GHVMHQICAQ TDFARFSGTN
VETDFVEVPS QMFENWVWEK EPLQQMSRHY KDESHVGDTL LEKLAASRLA NTAALIFRAT
HRTKIPLHSS PCDFFTYQLC SFRIGGGEVL GFLLFFFFFS QILTFCFIFY QAGMKYRNLI
LKPGGSLDGM DMLQNFLDRK PSQRAFLLSK GLCVQ
//
