ID A0A091V095_NIPNI Unreviewed; 1186 AA.
AC A0A091V095;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE Flags: Fragment;
GN ORFNames=Y956_15238 {ECO:0000313|EMBL:KFQ96719.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ96719.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ96719.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ96719.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KL410453; KFQ96719.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091V095; -.
DR STRING; 128390.A0A091V095; -.
DR eggNOG; KOG1025; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR CDD; cd00064; FU; 3.
DR CDD; cd05108; PTKc_EGFR; 1.
DR CDD; cd12093; TM_ErbB1; 1.
DR Gene3D; 6.10.250.2930; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044912; Egfr_JX_dom.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR049328; TM_ErbB1.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF91; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR Pfam; PF21314; TM_ErbB1; 1.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 5.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000619-
KW 2}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFQ96719.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 620..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 686..953
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 811
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 692..700
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 719
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ96719.1"
FT NON_TER 1186
FT /evidence="ECO:0000313|EMBL:KFQ96719.1"
SQ SEQUENCE 1186 AA; 132006 MW; C0CB1594D7687721 CRC64;
VCQGTNNKLT QLGHVEDHFT SLQRMYNNCE VVLSNLEITY VEHNRDLSFL KTIQEVAGYV
LIALNMVDVI PLENLQIIRG NVLYDNSYAL AVLSNYHMNK TQGLRELPMK RLSEILNGGV
KISNNPKLCN MDTVLWNDII DTSKKPLTVL EFASNLSSCP KCHPNCTEDH CWGPGEQNCQ
TLTKVICAQQ CSGRCRGKVP SDCCHNQCAA GCTGPRESDC LACRKFRDDA TCKDTCPPLV
LYNPTTYQMD VNPDGKYSFG ATCVRECPHN YVVTDHGSCV RSCNTDTYEV EENGVRKCKK
CDGLCSKVCN GIGIGELKGI LSINATNIDS FKNCTKINGD VSILPVAFLG DAFTKTLPLD
PKKLDVFKTV KEISGFLLIQ AWPDNATDLY AFENLEIIRG RTKQHGQYSL AVVNLKIQSL
GLRSLKEISD GDVAIMKNKN LCYADTMDWH SLFATQSQKT KIIQNRNKNE CAAARHVCDP
LCSDVGCWGP GPFHCFSCRF FDRQKECVKQ CNILQGEPRE FERDSKCLPC HPECLVQNST
AYNATCTGPG PDNCIKCAHF IDGPHCVKSC PAGVLGENDT LVWKYADSNA VCQLCHPNCT
RGCKGPGLEG CPNGSKIPSI AAGVVGGLLC LVVVGLGIGL YLRRRHIVRK RTLRRLLQER
ELVEPLTPSG EAPNQAHLRI LKETEFKKVK VLGSGAFGTV YKGLWIPEGE KVKIPVAIKE
LREATSPKAN KEILDEAYVM ASVDNPHVCR LLGICLTSTV QLITQLMPYG CLLDYIREHK
DNIGSQYLLN WCVQIAKGMN YLEERRLVHR DLAARNVLVK TPQHVKITDF GLAKLLGADE
KEYHAEGGKV PIKWMALESI LHRIYTHQSD VWSYGVTVWE LMTFGSKPYD GIPASEISSV
LEKGERLPQP PICTIDVYMI MVKCWMIDAD SRPKFRELIA EFSKMARDPP RYLVIQGDDR
MHLPSPTDSK FYRTLMEEED MEDIVDADEY LVPHQGFFNS PSTSRTPLLS SLSATSNNSA
TTCIDRNGQG HPVREDSFVQ RYSSDPTGAF LEDSIDDGFL PAPEYVNQLV PKKASASAVQ
NPIYNNFSLT ANSKVPTDSS YQNSHSTAVD NPEYLNTNQS PLAKTAFESS PYWIQAGNHQ
INLDNPDYQQ DFLPKETKPN GLLKVPAAEN PEYLRVAAPK SEYIEA
//
