ID   A0A091VDH9_OPIHO        Unreviewed;       822 AA.
AC   A0A091VDH9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=N306_00178 {ECO:0000313|EMBL:KFR00468.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR00468.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR00468.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR00468.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
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DR   EMBL; KK733857; KFR00468.1; -; Genomic_DNA.
DR   RefSeq; XP_009937491.1; XM_009939189.1.
DR   AlphaFoldDB; A0A091VDH9; -.
DR   STRING; 30419.A0A091VDH9; -.
DR   GeneID; 104333654; -.
DR   KEGG; oha:104333654; -.
DR   CTD; 9870; -.
DR   OrthoDB; 5480520at2759; -.
DR   PhylomeDB; A0A091VDH9; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11254:SF340; APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1; 1.
DR   PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR   Pfam; PF00630; Filamin; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   REPEAT          118..158
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   DOMAIN          482..822
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          312..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        789
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   822 AA;  94185 MW;  E42C1E10BABAA7C6 CRC64;
     MFYIIGGITV SVVAFFFTIK FLFELAARIV SFLQHEDRER RGERTIYDYV RGNYLDPRSC
     KISWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HICHVELAID IPVTQEVLQE
     PNSNVVKVAF TVRRAGRYEI TVKLGGLNVA YSPYYKVFQP GMVVPSKTKI VCHFSTLVLT
     CGQQHTLQIV PRDEYDNPTS NSVSLIDEHN YSLSIHELGP QEETSDVVFE KSVVSNRQTC
     EVFFRLTLHC RGCFHACISY QNQPISNGDF DIIVLSENEK NIVERNVSTS GVSIYFEAYL
     YDAPSYTNTQ WQLPPTHLSS SQRRPSTATE DEDEDSPSDS QTPEKVKKPK KVYCYVSPKQ
     FSVKEFYLKI IPWRLFTFRV CPGTKFSYLG PDPVHKLLTL VVDDGIQPPV ELSCKERNIL
     AATFIRSLHK NIGGSETFQD KVNFFQRELR QVHMKRPHSK VTLKVSRHCL LESSFKATRN
     FSVSDWSKNF EVIFQDEEAL DWGGPRREWF ELICKALFDT TNQLFTRFSD NNQALVHPNP
     GRPTYLRLKV YEFAGRLVGK CLYESSLGGA YRQLVRARFT RSFLAQIIGL RMHYKYFETD
     DPEFYKSKVC FILNNDVSEM DLVFAEEKYS KTGQLEKVVE LLTGGAQVPV TNENKILYLN
     LLAQYRLASQ VREEVDHFLK GLNELVPENL LAIFDENELE LLMCGTGDIS VCDFKAHAVV
     VGGSWHFREK VMRWFWTVVS SFTQEELARL LQFTTGSSQL PPGGFAALCP SFQIIAAPTH
     STLPTAHTCF NQLCLPTYDS YEEVHKMLQL AISEGCEGFG ML
//