ID A0A091W6V0_OPIHO Unreviewed; 489 AA.
AC A0A091W6V0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Interferon-induced, double-stranded RNA-activated protein kinase {ECO:0000313|EMBL:KFR10543.1};
DE Flags: Fragment;
GN ORFNames=N306_08928 {ECO:0000313|EMBL:KFR10543.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR10543.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR10543.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR10543.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC {ECO:0000256|RuleBase:RU000304}.
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DR EMBL; KK734738; KFR10543.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091W6V0; -.
DR STRING; 30419.A0A091W6V0; -.
DR PhylomeDB; A0A091W6V0; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR PANTHER; PTHR11042:SF163; INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:KFR10543.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW Transferase {ECO:0000313|EMBL:KFR10543.1}.
FT DOMAIN 4..72
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 99..167
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 280..489
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 239..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 309
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 489
FT /evidence="ECO:0000313|EMBL:KFR10543.1"
SQ SEQUENCE 489 AA; 55286 MW; 92FF0363C828F7BE CRC64;
MERECMDKIN SYCQKQKLRL VYDDVSMTGP SHDPEFTVVV KINNRVYGTG TGKNKKEAKA
AAAKKTWEMI EEKPESPSNM QPAELMTTPV TVPPVPGNDF VSILNMYSQK SLQKVDYPNK
ERTGDAHAPM FSCSCTVSGV LYGTGTGNTS AAAKQAAAKQ AFEKLNMEGA LTVYMLSYNT
NRGLYYKMVF LLFFNNSNIC FEDSTPKLAV CEKPLPSQRD AQSSALKFKR KLAANFDNAR
NKEEKKKTSD SDESLPDLDT NTGEENESPH TVNKRFLESF KNIEPIGEGG FGNVFKATAK
LDERTYAVKR VRFTENVKRE VKGLAGLEHE NIVRYYCSWK GYDHVTYPDS RQKSDTVLCL
FIQMELCEQG TLEDWIQNNR QNRKYHKMAQ TKFLQILTGV EHIHSKGLIH RDLKPLNIFI
SHEDKIKIGD FGLVTSVAYG TLTENRGTKS YMAPEQVGDR YGKEVDIYAL GLIWFEMLSA
LSCHEKTKV
//
