ID A0A091WPX9_OPIHO Unreviewed; 1376 AA.
AC A0A091WPX9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Hepatocyte growth factor receptor {ECO:0000256|ARBA:ARBA00019839};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE AltName: Full=HGF/SF receptor {ECO:0000256|ARBA:ARBA00033136};
DE AltName: Full=Proto-oncogene c-Met {ECO:0000256|ARBA:ARBA00033117};
DE AltName: Full=Scatter factor receptor {ECO:0000256|ARBA:ARBA00030820};
DE AltName: Full=Tyrosine-protein kinase Met {ECO:0000256|ARBA:ARBA00033031};
GN ORFNames=N306_00647 {ECO:0000313|EMBL:KFR17694.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR17694.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR17694.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR17694.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; KK736150; KFR17694.1; -; Genomic_DNA.
DR STRING; 30419.A0A091WPX9; -.
DR PhylomeDB; A0A091WPX9; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd05058; PTKc_Met_Ron; 1.
DR CDD; cd11278; Sema_MET; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625:SF61; HEPATOCYTE GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000617-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|PIRSR:PIRSR000617-3};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000617-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFR17694.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1376
FT /note="Hepatocyte growth factor receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001883806"
FT TRANSMEM 926..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..515
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 1073..1340
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 1199
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-1"
FT BINDING 1079..1087
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT BINDING 1105
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1152..1155
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT BINDING 1203
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT MOD_RES 1229
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1230
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1344
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1351
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT DISULFID 97..100
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 132..140
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 172..175
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 298..363
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 526..557
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
SQ SEQUENCE 1376 AA; 153818 MW; E8CA2E877CA4EAFA CRC64;
MKPFTAYPSG FIVFLFALLQ RSHGQCKEAA KKSEMDLSVK YDLPNFIAET PIQNVVLYKH
HVYIGAVNKI YVLNETLQNI SVYKTGPVLE NPDCAPCEDC KDKANLSNSV WKDNVNMALL
LETYYDDQLI SCGSVSGGVC HRHIIHPDNP ADIESEVHCM YSPRVDGEAD NCPDCVVSTL
GTKVLVTEKD RFVNFFVGNT VTSTLQPPYV LHSISVRRLK ETQDGFEFLT DQSYIDILPQ
FRDSYPISYV HAFENDHFVY FLTVQRESLD SQTFHTRIIR FCTLDSEMRS YMEMPLECIF
TEKRRKRSIR KEVFNILQAA YVSKPGAALA HEMGLGLNDD ILYGVFAQSK PDSSEPTNRS
AVCAVSVRTI NEFFNKIVDK QNMKCLQHFY GKESKYCLNR AFSRNASYCR AQDDEYRLEV
TTPLQRVDLF MGQFNSVLLT SISVFTKGNL TVANLGTSEG RFMQIVVSRS ELTAPHVSFQ
LDSHPVSPQV VVENSVADDG YTLVVTGKKV TKIPLAGPGC HHLRPCSRTY SILSVEFLCC
RELSNAKFHS IYNFGVCLLS VTTCAIAPLE GGTKLTLCGW DFGFSKNNRF ELKNTVVHIG
GQICALEAKS SNKNKLECTV PAAKNPTFNI SSSVSVGHGK TQFNTFSYVN PVITSISPTY
GPKSGGTLLT IAGKYLNSGK SRRIFVGEKP CTLKSVSVST VECYTPAQRI PQEYRVRVGI
DEAIRDASGH FTYREDPVVL KIHPAKSFLS GGSTITAQGI NLNSVCFPQM VITVPKLGMN
FSVACSHRSS SEIICCTTPS LKAFNLQPPF VTKMFFIFDG VSSLYFDFDY VNNPVFKHFE
KPVLISRGNP SILEIKGNYI DSEAVKGEVL KVGNKSCENL LLQSESILCT VPSDLLKSNS
ELNIEWKQEV LSTVIGKVLI RQDQNFTGLI AGVVSTSVLI CIFLMVFLWR RKKKQIKDLG
SDLVRYDGRV HTPHLDRLVS ARSVSPTTEM VSSESVDYRS TFPEDQFPSM SQNGSCRPAQ
YPHSDLSPIL SSGDSDLASP LLQTNVHIDI SALNPDLVKE VQHVVIGADS LIVHFSEVIG
RGHFGCVYHG TLLDNDGRKI HCAVKSLNRI TDLEEVAQFL KEGIIMKDFT HPNVLSLLGI
CLPNEGSPLV VLPYMKHGDL RNFIRNETHN PTVKDLIGFG LQVAKGMKYL ASKKFVHRDL
AARNCMLDEK FTVKVADFGL ARDVYDKEYY SVHNKTGAKL PVKWMALESL QTQKFTTKSD
VWSFGVLLWE LMTRGAPPYP DVNSFDITVY LLQGRRLLQP EYCPDPLYEV MLKCWHPKPE
MRPAFSELVS KISTIFSTFI GEHYVHVNAT YVNVKCIAPY PSLLSSQDNT DTDVDT
//
