ID A0A093CCS2_TAUER Unreviewed; 709 AA.
AC A0A093CCS2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Guanine nucleotide exchange factor VAV2 {ECO:0000313|EMBL:KFV13730.1};
DE Flags: Fragment;
GN ORFNames=N340_01627 {ECO:0000313|EMBL:KFV13730.1};
OS Tauraco erythrolophus (Red-crested turaco).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; Tauraco.
OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV13730.1, ECO:0000313|Proteomes:UP000053661};
RN [1] {ECO:0000313|EMBL:KFV13730.1, ECO:0000313|Proteomes:UP000053661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV13730.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL462075; KFV13730.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093CCS2; -.
DR Proteomes; UP000053661; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20868; C1_VAV2; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd10406; SH2_Vav2; 1.
DR CDD; cd11980; SH3_VAV2_1; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035880; VAV2_SH2.
DR InterPro; IPR035733; VAV2_SH3_1.
DR PANTHER; PTHR45818:SF4; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053661};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..52
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 126..304
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 333..435
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 446..495
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 513..579
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 600..694
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 218..245
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV13730.1"
FT NON_TER 709
FT /evidence="ECO:0000313|EMBL:KFV13730.1"
SQ SEQUENCE 709 AA; 82579 MW; A95AD0B2EE609D8B CRC64;
QFLCLKNIRT FLKVCHDKFG LRNSDLFDPF DLFDVRDFGK VISAVSRLSF HSIAQTKGIR
PFPSEETTEN DDDVYRSLEE LADEHDLGED IYDCVPCEDE GDDIYEDIIR VEVQQPMKMG
MTEDDKRNCC LLEIQETEAK YYKTLEDIEK NYMNPLRLVL TPQDMEAIFI NLEDLIKVHF
SFLRAIDVSM MSGGSSLAKV FLEFKERLLI YGKYCSHMEY AQNTLNHLLA NREDVRQKVE
ECTLKVQDGK FKLQDLLVVP MQRVLKYHLL LKELLSHSSD RPEKQQLKEA LEAMQDLAMY
INEVKRDKET LKKISEFQSS IENLQVKLEE FGRPKIDGEL KVRSIVNHTK QDRYLFLFDK
VVIVCKRKGY NYELKEIIEL LFHKMTDDPM NNKDIKKWSY GFYLIHLQGK QGFQFFCKTE
EMKRKWMEQF EMAMSNIKPE KANANHHSFQ MYTFEKTTNC KACRMFLRGT FYQGYLCPKC
GAGAHKECLE IIPPCKIGSS ADQGLSDETF ASAPGPKMVA VQNYHGNPAP PGKPVLTFQI
GDVIELLRGD PDSPWWEGRL LQTKKSGYFP SSSVKPCPVD ARPPNSRPPS REIDYTAYPW
FAGNMERQQT DNLLKSHVSG TYLIRERPAE AERFAISIKF NEEVKHIKVV EKDNWIHITE
AKKFESLLEL VEYYQSHSLK ESFKQLDTTL KYPYKSRERS TSRTFTRSP
//
