ID A0A093EKV6_TYTAL Unreviewed; 832 AA.
AC A0A093EKV6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Rho GTPase-activating protein 12 {ECO:0000313|EMBL:KFV45504.1};
DE Flags: Fragment;
GN ORFNames=N341_04828 {ECO:0000313|EMBL:KFV45504.1};
OS Tyto alba (Barn owl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto.
OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV45504.1, ECO:0000313|Proteomes:UP000054190};
RN [1] {ECO:0000313|EMBL:KFV45504.1, ECO:0000313|Proteomes:UP000054190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV45504.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK375151; KFV45504.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093EKV6; -.
DR Proteomes; UP000054190; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12070; SH3_ARHGAP12; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035491; ARHGAP12_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF107; RHO GTPASE-ACTIVATING PROTEIN 12; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16618; SH3-WW_linker; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000054190};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 12..74
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 257..290
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 356..383
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 460..561
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 642..830
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 191..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV45504.1"
FT NON_TER 832
FT /evidence="ECO:0000313|EMBL:KFV45504.1"
SQ SEQUENCE 832 AA; 94663 MW; 197B05E5E2FEB230 CRC64;
VEMADKGGKI IPGQLYIEVE YDYEYEAKDK KIVIKQGEKY ILVKKTNDDW WQVKGDENSK
PFYVPAQYVK EIPRKALMPP VKQASMLPNN ALKLTHGLQR STENVNKSPE LSSFGKSSPV
QVSCLVRDAN QNLGVNNSPG QTLGLSLDLT QNNGKLNNEL QSPKVSNQYR TVSMGHFPCP
EFLEIEKTSF LHEQSEGSEK IHQDSESGDE LSSSSTEQVQ PTTPPSQGRP DSPVYANLQE
LKISQSALPP LPTSAPVQIN GEWETHKDTT GRCYYYNRGS QERTWKPPRW ARDASINKGD
SHSHADHEHL SSEENDHSSC YSQSDSQYGS PPKGWSEELD EHGQTLYTND YTNEKWIKHA
DEQGRPYYYS ADGSRSEWEL PKYNASPQQQ RDIIKSRSLD RRLQEPIVLT KWRHSTIVLD
TNDKESSSAS KASFPENESS SSPKHQATGQ EKYGLLNVTK ITENGKKVRK NWMSSWAVLQ
GSSLLFTKTQ GSGTGWFGVN QSKPEFTVDL KGALIDWASK DKSSKKNVIE LKTRQGTELL
IQSDNDSFIN EWYKVLNYTI NNQVIESDET LEDEIPDSPG VEKQDKEKEN KDSKKLRLKA
PSNIDSTDQK KTKTKLKKFL TRRPTLQAVR EKGYIKDQVF GSNLTSLCQR ENSTVPKFVK
LCIEHVEEHG LDVDGLYRVS GNLAVIQKLR FAVNHDEKLD LNDSKWEDIH VVTGALKMFF
RELPEPLFTY NHFNDFVNAI KQEPRQRVHA VKDLIKQLPK PNQDTMQVLF RHLKRVVENG
EKNRMTYQSV AIVFGPTLLK PEKETGNIAV HTVYQNQIVE LILLELNSIF GR
//
