ID A0A093EQE7_TYTAL Unreviewed; 120 AA.
AC A0A093EQE7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Thioredoxin domain-containing protein 12 {ECO:0000256|ARBA:ARBA00016955};
DE EC=1.8.4.2 {ECO:0000256|ARBA:ARBA00013094};
DE Flags: Fragment;
GN ORFNames=N341_05602 {ECO:0000313|EMBL:KFV42264.1};
OS Tyto alba (Barn owl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto.
OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV42264.1, ECO:0000313|Proteomes:UP000054190};
RN [1] {ECO:0000313|EMBL:KFV42264.1, ECO:0000313|Proteomes:UP000054190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV42264.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-disulfide + 2 glutathione = [protein]-dithiol +
CC glutathione disulfide; Xref=Rhea:RHEA:21064, Rhea:RHEA-COMP:10593,
CC Rhea:RHEA-COMP:10594, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.8.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00033687};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:21066;
CC Evidence={ECO:0000256|ARBA:ARBA00033687};
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DR EMBL; KK368334; KFV42264.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093EQE7; -.
DR Proteomes; UP000054190; Unassembled WGS sequence.
DR GO; GO:0019153; F:protein-disulfide reductase (glutathione) activity; IEA:UniProtKB-EC.
DR CDD; cd02959; ERp19; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR037462; ERp19.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR15337; ANTERIOR GRADIENT PROTEIN-RELATED; 1.
DR PANTHER; PTHR15337:SF10; THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12; 1.
DR Pfam; PF13899; Thioredoxin_7; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054190};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..104
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV42264.1"
FT NON_TER 120
FT /evidence="ECO:0000313|EMBL:KFV42264.1"
SQ SEQUENCE 120 AA; 13457 MW; 8D51394822F897FB CRC64;
SGLPLMVIIH KSWCGACKAL KPKFAESKEI SELAHNFVMV NLEDDEEPKD EAFSPDGGYI
PRILFMDPSG NVHPEIINEK GNPSYKYFYT NADQVVQGMK EAQEKLTGDA FKQKHLGDEL
//
