ID A0A093HX20_STRCA Unreviewed; 488 AA.
AC A0A093HX20;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Sorting nexin-2 {ECO:0000256|ARBA:ARBA00020435};
DE Flags: Fragment;
GN ORFNames=N308_13676 {ECO:0000313|EMBL:KFV86186.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV86186.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV86186.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV86186.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; KL206825; KFV86186.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093HX20; -.
DR STRING; 441894.ENSSCUP00000023145; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd07664; BAR_SNX2; 1.
DR CDD; cd07282; PX_SNX2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037918; SNX2_PX.
DR InterPro; IPR005329; Sorting_nexin_N.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR PANTHER; PTHR10555:SF31; SORTING NEXIN-2; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF03700; Sorting_nexin; 1.
DR Pfam; PF09325; Vps5; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 105..234
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 401..435
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV86186.1"
FT NON_TER 488
FT /evidence="ECO:0000313|EMBL:KFV86186.1"
SQ SEQUENCE 488 AA; 55236 MW; 56F66745EE0B8271 CRC64;
QSSPSSPEPA SLPAEDLSTN SNGPKPAEIM LDDDREDLFA EATEEVSLDS PERDPILSPE
PTPAITPVTP TTLVAPRMES KSVTAPVIFD RSREEIEEEA NGDLFDIEIN VSDPEKVGDG
MNAYMAYRVT TKTSLSMFHK NEFSVKRRFS DFLGLHSKLA TKYMHVGYIV PPAPEKSIVG
MTKVKVGKED SSSTEFVEKR RAALERYLQR TVKHPTLLQD PDLRQFLESS ELPRAVNTQA
LSGAGILRMV NKAADAVNKM TIKMNESDAW FEEKQQQFEN LDQQLRKLHA SVEALVCHRK
ELSANTAAFA KSAAMLGNSE DHTALSRALS QLAEVEEKID QLHQEQAFAD FYVFSELLGD
YIRLIAAVKG VFDHRMKCWQ KWQDAQVTLQ KKREAEAKLQ LANKPDKLQQ AKDEIKEWET
KVQQGEKDFE QISKTIRKEV GRFEACIIRE RVKDFKTVII KYLESLVQTQ QQLIKYWEAF
LPEAKAIA
//
