ID A0A093IN08_FULGA Unreviewed; 4267 AA.
AC A0A093IN08;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 39.
DE SubName: Full=Polycystin-1 {ECO:0000313|EMBL:KFW04080.1};
DE Flags: Fragment;
GN ORFNames=N327_09468 {ECO:0000313|EMBL:KFW04080.1};
OS Fulmarus glacialis (Northern fulmar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC Fulmarus.
OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW04080.1, ECO:0000313|Proteomes:UP000053806};
RN [1] {ECO:0000313|EMBL:KFW04080.1, ECO:0000313|Proteomes:UP000053806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW04080.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; KK597386; KFW04080.1; -; Genomic_DNA.
DR Proteomes; UP000053806; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd00146; PKD; 9.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR006228; Polycystin_cat.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR NCBIfam; TIGR00864; PCC; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR PANTHER; PTHR46730:SF3; POLYCYSTIN-1; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00801; PKD; 14.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00369; LRR_TYP; 1.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00089; PKD; 15.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 13.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50093; PKD; 10.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053806};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2995..3017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3203..3224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3244..3266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3487..3509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3515..3534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3601..3621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3825..3844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3864..3884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3904..3923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3949..3971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4008..4036
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..203
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 237..269
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 347..461
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 895..951
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 987..1059
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1077..1139
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1173..1230
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1247..1320
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1349..1404
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1422..1479
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1658..1744
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1994..2077
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2080..2762
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 3040..3155
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 4086..4116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4169..4224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4241..4267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4090..4116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4199..4214
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4252..4267
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW04080.1"
FT NON_TER 4267
FT /evidence="ECO:0000313|EMBL:KFW04080.1"
SQ SEQUENCE 4267 AA; 472692 MW; 0FD19F56159AA95D CRC64;
FSFSRDLSNN KISGLDVQIF ESLASLEKLD ISHNKISTLE DGIFDNLFNL SEINLSWNPF
VCDCKLSWLP LWVEDRKVKV IEASDTRCAR PPEVANLSLF SVLFLNATCG AQHITCLTSN
HTEGAELVIL FTSVHPGNLT EESCSALCYA EDQEYGGFSS QGQCLCGTAH ETNSSSSCLP
FCTEHLSGQA CGGPSLVPSP FQAQLPVSFT GLQPQYSLHQ AVLFNVSIPI AVSTLLWEFG
DQTEVLNTTG NAAVHMYALP GQYNVTATIF VGTKVLYVQA EIEVVASPQQ LELQCPSLVK
TNESLDIRIR NRGGTGLVVL YGITAEAGEL GRAVHPTCPP DGLVFPGNNH CYQLVVEKAE
WLEAQQHCQE HGNGELAFVS SPEIQSFLVA HVIRSLDVWI GFNDFASTGA QQRSEGFNLE
SCQNWLPGEP HPSNADHCVR MGPTGQCNTD LCMAKHSYVC EYKPKGVLLN AENFFVGDPV
FDTHEAVKNV TEDVLSAPWQ AVEVMVFHEL AFRHEGYLTA LEFVTQELHQ PVQVRFQVHR
PINGEDCQEG KNATEPFHTA QDDGNWTLLE CPPGFQWCHL TNLCSSLNNC CNATECANSS
LASSPIPVSL QHNESQLSYE LIKEFLFTIP AGPSSQYLVT FRKESIFVRA KDIFSIQHNA
GLGLLLQCQP STTSPYRTNV LSTNSSEWAL GLSDSSVGAT WINNTVCSLR VRYAEEQLVP
VISPHNAGLE HTGRYMVRAS VDNGVFSANL SCSFWVASRV SGLRVIHPAP QGSRVYLPSN
HTTLVIKLSS GVNATASWLG DNHTFPFEGS CPAAVAPLTA DCARETNDTW FAVVSLSSLR
EGVSTHVLVA ENAVSSQNIT VTVKVEEPIR GLRATPDPES RVLLNTRVSY VPVMEAGSDV
TFRWTVDDKP SFTFYNVVFN VIYQSPAVYK LSLTASNHVS NFTVNYNVTV EMMNKMKNLT
VLGVLPVLPQ NSTVELTARV QVDSAVDAMF LWDFGDGVQE TYLFRPPYNK SFLVPDPSVH
EVVIEHNVSH IYQDPGEYAL VVLVSNQFEN LTHLTPVHIH SYLIDVKVEV EEDVLVVSRP
VTFRANPLPS PYGVVYTWDF GDGSSLFTES QSMVTYSYSR RGVYNITVTA NNTISSVETV
ECYQVFEEIT GLHVWADEAA ELGASVTLNA SVQSGDSITW IFDMGDGTVL RSQVPVVEHV
YVKDINCTVN VTAVNLVNSV SQTVPVRIFV LEVLKIEPTS CILEHPDVQL TAYVTGNPDE
YIFDWTFGDG SSNVTISGDP VVMHNFTRSG TFPLSLTLSS RFNKAHYFTS VCVEPEIVNV
TLLPSKQFVR LGEESSFQVS AVPLYQYRYR WDFGNNESTR SSGTEVTYTY KNTGVFLVTV
TVSNNVSFNN DTAFVEVQEP VGVAKIEYNG TSVLELNQIY LFSASMNGTK VSYCWDFGDG
TTQPGQIATH SYNNTGHYTI SVMGQNDVSF NETIINVTVK RRLHGLTINA SRTVVPLNGS
VSFVATLVAG SAIRYSWILC DRCTPIQGSS TISYTFRSVG TFNVIVTAEN KISSLQDSIY
VYVLEQIEGL QVASSDLVED IYFPTNKTLH LQAVVREGTN ISYSWVAQRD GNALQTFTGK
TFSLSILEAG NYTVYLKATN MLGCATANRT LEFVESIGLL KPYAFPNPVA INASVNISTT
ITSGTGITYV WYLEDGFSPV TSEPFIVHSF QSPGVIEVVI GAENKLDSTN ATIYICVEEV
IEGLSIGTAE LDCRYVSSGS TVVFEGELQK GTEVTWLWEV PNGTLTGQSV AVMFPTAGFY
TVYLNASIAG ISQNISVLDR IQGLEVLASK KVVEPGEQVT FVIRMLSGTS VSYLVSISGD
YSVVLNGSRY THEFTKSGDY LVTVTVQNQI SIAHAQVLIS VLEAIHDVRL LNCCEEGIPT
GTEKSFSAQV GSGSRVSFSW QFSLWKEQGR SVVTVSGESV SYTPEAAGLL EIHLNAFNDL
GGINITRTIQ VQDPIVQVFL TASNAFVNRT ALFEAAVVPS SKSVEFLWTF GDGSSTQMTR
VAVANYSYLS PGDYLVEVNA TNLISFFIAH LTVTVKVLEC EEPEVELALP PQVVMKRSQR
NYLEAQIDLR GCIKYQTEHL WEIYRAPSCM NLDDSSRIHL PNVDVNRPQL VIPKLALEVG
NYCFIFIVSF GDTPLSKSIF ANVTVIPSKL VPIIDGGSYR VWSNTQDLIL DGEKSYDPNL
DDGEQTPLLY DWSCTFSSKS SAAGCSLNFS AKEGIVTISK AVLEADVEYT FDLTVRKEGM
SPEATNQTVF IKRGGVPIVS LECVSCKAQS VYEVSKSSYV YLEGTCQNCH NDSKLGRWAA
HSFKNKSLIL DKKTTSTGDT GMNLVLRQGA LKDGEGYTFT LHITDLTTGE EGFASIDLLP
NQPPVGGSCR LSPKGPLRAL MAKVHFECAG WRDTEDAEGP LVYILLASRR RAGHYHEFCV
YKGSRAEHSA FLPPGFHESG FVVSVSVLVQ DQLGATVVAI NRSMEISLPE GFPSLSHWLY
NQTDTVLQGL VKQGDPQQVI EYSLALITIL NEYERSMLLE PETGNEFELR TWTRNNITET
LNSLNVNTVD DIQQISAALA QCTVVSKELV CKSCLTRTLN KLETMMTILQ GEMTKGTVTP
TGIADNILNI TGDLIHLVNT VSQESKPQEL LSDSHNLLLA PKAYNLSSSL MRILMKSRVL
NEEPLELVGG EIKATGKRSD PFNLLCYENT PNCQFSIPQA FNTTLSNLTD VIQVMFQVDS
NPFPFGYISN YTVSTKVASM EFQTHNGVQI PIGSLDSEKA ITVMVSNNTD ADNLSAGTEV
IEARTSVNLI VTMESNNREA GLHFQLTYRV LNDHYIASEP EPFIMAYLHH EPEPNEHNCS
ASKKIGLDAL AGSDHKLYTF FTSPRTDDTI QKYYFNITNH FSWSPVEVTL GLYTSLCQYF
SEQEKRWKTE GIIPLEETRP DQAVCLTQHL TAFGASLFVP PNSVQFIFPA PGPGLNYIVL
LTCAVCFVTY SVAALIVHKL DMIDVNRVGV IPFCGKNGLY KYEILVKTGW GRGSGTTAHV
GIALYGVDNK SGHRHLDGEN AFHRNSLDVF QIATERSLGS IWRIRIWHDN KGLSPSWYLQ
HVIVRDLQSS KSYFFLVNDW LSVESEENDG MVEKEVYAAS ETELRSFSRI FIAELQRGFF
EKHVWLSMWD RPPRSRFTRV QRATCCSLLI FLFLCANAVW YGVVGNVHLS NGAVSNLIPV
NVDTVAVGLV SSVVVYPLYL VILFLFRMAR GKVSINHTLT HSDQQSLEID NYLDSSILDS
SFPTFPGLRA EAFSEQTKTD LFLEDSKSLV RWPSSEALLS WPDLLSDPSI MGNTIQKLKR
GRASRHLGLE GPLATEEDSL SLGVHQGQPR YFSASDENLI RQILADGASG ISHSQDLGPY
MRAETDLISG LSSVFGEKVE TVMMQKLNDK GQSMAAPPRE VSRSAKSTWT VADQTFRKRL
LPPWCSYLAH GISLLLFATS TGVSVWIGVG FSSSVALMWL ISGIFSFLAS FLVWEPLKVL
LEALYFSLVA KRLHPEEDDT LVEHPFVEHV SEKISKVRPP QGFALFQAKE EARKVKLLHR
ILKNFLIYMM FLLVILLTNY GDASRNSRAF LLQSSIKQQL GSNEFLRIKR SDQFWVWMSQ
VFLPYLYNNR SGQESYSTTL GTARLRQLRL QEGRRSCTDS HSFSTADYAA GWERVAVNVT
AAWSYSPPDL TGVWYWGYIS FYDSSGYVQE LGASLEESRA QLNFLQQHAW IDNMSRAVFV
ELMQYNPSVD LHTAITLQLE FLGAGQAVAA VTISPFPLLR LSGGVTLQLL MMVFLMMFVV
YFVVSESLSI KKEGRAYFTL WGNYGQWIFI LLTTCTVVVH LSQATLADQQ WLKYLNNRKG
FTNFYQVAFL NTIFSTLAVL LTVQAAQQLR FVRQWSVFGK TFQKSARELT AAGLAFAVLI
LAYAQLGFLL FSSSSESFRS VGSSLLLLFA MLRGSVNLRP CLPESSGLYY LFCTSYIILE
VWIVLRLFTV VLIYSYREMH FELYRPAFEP QDYEMVELFV RRLKMWMGFS KAKEFRHKVR
FEGMEPLPSR DSSDSKSFRG PTPSAASDSS RASTSSSQLD GLSLVLSTRD SLEVDADIQR
LLSLFEMLLA QFDRVNQVTE DVYRIEHQLE GSRSRRSRRR YCAGSTEQGP SPEISSDTPR
DAPLPPPSPA APPGSRGSVP SRLLRASRGI SVAASVLPPH KPYATVAPAV KKKRPLRAKN
RVHPTVK
//
