ID A0A093IWI1_FULGA Unreviewed; 627 AA.
AC A0A093IWI1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
DE Flags: Fragment;
GN ORFNames=N327_04413 {ECO:0000313|EMBL:KFW03977.1};
OS Fulmarus glacialis (Northern fulmar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC Fulmarus.
OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW03977.1, ECO:0000313|Proteomes:UP000053806};
RN [1] {ECO:0000313|EMBL:KFW03977.1, ECO:0000313|Proteomes:UP000053806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW03977.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR EMBL; KK597124; KFW03977.1; -; Genomic_DNA.
DR RefSeq; XP_009574988.1; XM_009576693.1.
DR AlphaFoldDB; A0A093IWI1; -.
DR GeneID; 104076001; -.
DR KEGG; fga:104076001; -.
DR CTD; 4952; -.
DR OrthoDB; 21647at2759; -.
DR Proteomes; UP000053806; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF176; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053806}.
FT DOMAIN 443..627
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW03977.1"
FT NON_TER 627
FT /evidence="ECO:0000313|EMBL:KFW03977.1"
SQ SEQUENCE 627 AA; 72576 MW; 95AAFB2B2CEC812B CRC64;
FQELDLSTEA FFYLDSAKEQ EWLAAVEKSL HPQAKYKKVQ MVRLVGMMLL IFARKDQLSN
IREIMTESVG TGIMGKMGNK GGVAVRFVFH NTTFCIVNSH LAAHVEDFER RNQDYKDICA
RMSFVTPDDS LPQLNIMKHD VVIWLGDLNY RLCLPDASEV KSLISKNELQ KLLTYDQLNI
QRTQKKAFAD FIEGEIKFIP TYKYDSKTDR WDSSGKCRVP AWCDRILWRG GNINQLRYCS
HMDLKTSDHK PVSALFRIGV KVVDEQRYRK LFEDIVRIMD RMENDFLPSL ELSRRDFEFK
NVKFRQLQKQ KFQITNNGQV TCHFSFIPKL NDSHYCKPWL RAEPCEGYLE PDESTDISLD
VYVSKDSVTL LNSGEDKIED ILVLHLDRGK DYFLTISGTY LPSCFGTSLE ALCRMRRPIR
EVPVTKLIDL GEDSFLEKEK SVLPLGSMDS EEGSGMPLQV PKEIWLLVDH LFKHACHQED
LFQTPGMQEE LEQIIDCLDT SIPETIPGSN HSVAEALLIF LEALPEPVIC YELYQRCLDW
SHNSRLCQQA IFQLPRCHRS VFQYLMLFLR ELLKYSEDNN VSVAMIAALF SSLLLRPPPN
LMAKQTQQDR QRAINFLYSF LLAGDEE
//
