ID A0A093J6I1_EURHL Unreviewed; 886 AA.
AC A0A093J6I1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain H2 {ECO:0000313|EMBL:KFW06594.1};
DE Flags: Fragment;
GN ORFNames=N326_07688 {ECO:0000313|EMBL:KFW06594.1};
OS Eurypyga helias (Sunbittern) (Ardea helias).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Eurypygiformes;
OC Eurypygidae; Eurypyga.
OX NCBI_TaxID=54383 {ECO:0000313|EMBL:KFW06594.1, ECO:0000313|Proteomes:UP000054232};
RN [1] {ECO:0000313|EMBL:KFW06594.1, ECO:0000313|Proteomes:UP000054232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N326 {ECO:0000313|EMBL:KFW06594.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR EMBL; KK569663; KFW06594.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093J6I1; -.
DR Proteomes; UP000054232; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF14; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000054232};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..125
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 250..433
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW06594.1"
FT NON_TER 886
FT /evidence="ECO:0000313|EMBL:KFW06594.1"
SQ SEQUENCE 886 AA; 99432 MW; 4213F90761710217 CRC64;
QLQVEDDDKI GLYSYKVQST ITSRLANTMI QAKMVNNAKR SQHIVFDVQV PKGAFIDNFT
MDVNGITFTS KIREKSEARK MYSQAKAKGK AAGIVRSNAL DMENFKTEVN VPPGTRIQFE
LHYHEMIRRK LSSYEHLISV KPGRLAKHME VDVRIIEPQG LRYVHVPNSL GDHFNGITTI
SKGEKKAHVS FKPTMAQQRK CPTCSSTAVD GNFVVQYDVN RETTGGELEI FNGYFIHFFA
PENLDPLPKN ILFVIDVSGS MWGLKMKQTI EAMKAILSEL RAADQFSLID FNHNVRCWRD
NLVSATPAQV EDAKKYIQTI HPNGGTNINE ALLRATFILN EAQNLGMLDP NSVSMIVLVS
DGDPTVGELK LTTIQKNVKQ SIKDEFSLFC LGIGFDVDYD FLQRIATDNR GMAQRIFGNQ
ETSAQMKNFY NQVSTPLLKK IQFNYPQESV SDVTQSSFHN YFGGSEIVVA GKVDTDNLQH
LESIVTATAA NAELVMETLR DVEELDGFMK KDKYADPEFT RKLWAYLTVN QMLAERNTAP
TAALKRNITK SILQMSLDHH IVTPFTAMLI ENAEKDEIML ADQPKDPRRG CCPGTLGLTP
NAPNNNKGIP AWANVTAVPV SFMPEQRSPP VSSLSINRVD NDPHFIIHLP KSQRNICFNI
NSEPGKILNL VSDPGTGVVV NGQIVGAKKT ENKKLNTYFG KIGFYFKSKG LKVEITTKTI
TLKDGSYGIT LTWSDTGHII RKQLLISVKK ENNVTITVGE EMSFMVLLHR VWKNHPVNVD
FLGIYIPPEN QFSPAAHGLI GQFASEPEVY IHHQRPGQAP EKPQATMEVK GNKLTVTRGL
QKDYRRDRVA GTDVQCWFVH NSGKGFIDGH YRDYLVPHLY SFLKKP
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